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Description:
Probable DNA helicase II homolog (EC 3.6.1.-).
Molecular weight: 81959
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-MAR-2006, entry version 31.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRD_MYCGE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L43967 | AAC71464.1 | - |
| EMBL | X61517 | CAA43729.1 | - |
| PIR | I64226 | I64226. | |
| HSSP | P56255 | 1PJR | |
| GenomeReviews | L43967_GR | MG244.1 | |
| TIGR | MG244 | -. | |
| BioCyc | MGEN2097:MG244-MONOMER | -.1 | |
| InterPro | IPR000212 | UvrD-helicase. | |
| PANTHER | PTHR11070 | UvrD-helicase.1 | 1. |
| Pfam | PF00580 | UvrD-helicase | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=96026346; PubMed=7569993;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 277-345.
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=92051396; PubMed=1945886;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map
RT of Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
Feature:
CHAIN 1 703 Probable DNA helicase II homolog.
/FTId=PRO_0000102076.
NP_BIND 20 27 ATP (Potential).
Comments:
-!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA
duplexes with 3' to 5' polarity with respect to the bound strand
and initiates unwinding most effectively when a single-stranded
region is present. Involved in the post-incision events of
nucleotide excision repair and methyl-directed mismatch repair (By
similarity).
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 703
MNEQQKQAIS CGKGVNVVYS GAGTGKTTII TNRFAYLVNK EKVDPSRILA ITFTKKAAKE
MQFRILKLID SSLAEKTNIY TFHSFCNKFL IQTLKKRFII DDDISYFLKE FLADSKLDIN
LAKQIIDNFK NTFADFEINK LDQDERLISL CEHSLLNKDE EYSTLKTQLI NAFISYEKNK
ILNNKLDFHD LLIKTCNLLS NDNDLLNQWS EQFQHILVDE FQDTNQIQYE LIKMLVTKNK
NLFLVGDNNQ MIYRWRGAVN GIITALKHDF NVPKSNEFFI NQNYRCDQNI LAVANQILLK
IMAYEKQVKT EKNLLFSTLN SDKKPVYFQA ESVENQANWI FNKIKALNQT EKINFKDMAI
LFRKNRDITT MVELIEADGT IPLPKQKSYF NQLVKLQRVL IAISTRTNLD IKRALQALKI
WSNDLKELWK QSDKTNLFDF LKWSELNQKN HSSKLKATGY FNLLIKLAED QQINLLFTEL
FKKLKVDQTI ENLLWKKLTE FQKDKTEFSL SEFITSLALE FDSIIENSSD TINLLTVHAA
KGLEFEAVFI YGMNQGDFPL FLSQNQNDEQ HLIDELKLFY VAITRAKRFL FITAVLQINN
NSIKPSSFLN YINKSEYLDI ATINYVLEQD DDFFDSTKKT DYTKKLRKES LDIIVGDLVT
SRYFGKGVVV EVRDKEVLVA FKDTRYGMKW ILKNHKSLTK ALY