Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 27819
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_MYCPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U00089 | AAB96244.1 | - |
| PIR | S73922 | S73922. | |
| HSSP | P12295 | 1EUG | |
| GenomeReviews | U00089_GR | MPN235.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX MEDLINE=97105885; PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C.,
RA Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
Feature:
CHAIN 1 240 Uracil-DNA glycosylase.
/FTId=PRO_0000176116.
ACT_SITE 70 70 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 240
MEQLLDQFLS GVLSEWKAFI LQEAKQTYFQ ELLAKLKNVE QELTPKASQV FRPFSFFAPN
NTKLIIYGQD PYPNPQHACG LSFASNAPKL PQSLKRMILR LQQEYPELAG QNHWTKQLLE
GWAQQGILLL NGVFTTNAFQ TNAHRNWGWE QFNCHLLDFL LSQKLYVLLV FLGKQTENFV
LKKIGGASQF ASLSYPHPSP LTGRKFFDHP DALFKQINQW LKHHNHTPID WTNGQVQYQF