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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 35956
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_MYCPU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL445565 | CAC13831.1 | - |
| PIR | B90594 | B90594. | |
| HSSP | Q56313 | 1IN5 | |
| GenomeReviews | AL445566_GR | MYPU_6580.1 | |
| MypuList | MYPU_6580 | -. | |
| BioCyc | MPUL2107:MYPU_6580-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR000641 | CbxX_CfqX. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| PRINTS | PR00819 | CBXCFQXSUPER. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX MEDLINE=21267165; PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C.,
RA Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen
RT Mycoplasma pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
Feature:
CHAIN 1 315 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165561.
NP_BIND 46 53 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 315
MAKKQEIRPK NFSDFVGQNK LKKLLKVMIS SAQVQNRPLD HILFYGNPGT GKTSLASIIS
NSLNSRIKYA QGNLLDKKTD ILTLFASVEE NDIIFVDEIH AINKNIEELL YSILEDFVVD
IVIGVESNSK IMRLNLKPFT FIGATTQINR ISKPLRDRFG LIGQISNYQV EDIEKIIKNN
SKKLNIQIDE KATNLIALYS QNIPRLAINL LKRTKDFCIY EECQIIDYKL VNKTLKQLGI
YENGLNESQV KYLRSLSETF YKKAVSLDLI VGFLSLQKET IISEIEPLLI SNNLIVKTPR
GRKITQKGIS YLERI