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Description:
UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B).
Molecular weight: 75885
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVB2_MYCPU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U59874 | AAD00088.1 | - |
| HSSP | P56981 | 1D9X | |
| HAMAP | MF_00204 | - | 1. |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR006935 | ResIII. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004807 | UvrB_ABC. | |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF04851 | ResIII | 1. |
| Pfam | PF02151 | UVR | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00631 | uvrb | 1. |
| PROSITE | PS50151 | UVR | 1. |
Keywords:
ATP-binding; DNA damage; DNA excision; DNA repair; Excision nuclease; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=X1048;
RA Minion F.C., Jarvill-Taylor K.J.;
RT "Molecular analysis of the uvrB homologue in Mycoplasma pulmonis.";
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 660 UvrABC system protein B.
/FTId=PRO_0000138411.
DOMAIN 622 657 UVR.
NP_BIND 39 46 ATP (Potential).
MOTIF 92 115 Beta-hairpin.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. A damage recognition complex composed
of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon
binding of the uvrA(2)B(2) complex to a putative damaged site, the
DNA wraps around one uvrB monomer. DNA wrap is dependent on ATP
binding by uvrB and probably causes local melting of the DNA
helix, facilitating insertion of uvrB beta-hairpin between the DNA
strands. Then uvrB probes one DNA strand for the presence of a
lesion. If a lesion is found the uvrA subunits dissociate and the
uvrB-DNA preincision complex is formed. This complex is
subsequently bound by uvrC and the second uvrB is released. If no
lesion is found, the DNA wraps around the other uvrB subunit that
will check the other stand for damage (By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrA during the search for
lesions. Interacts with uvrC in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- DOMAIN: The beta-hairpin motif is involved in DNA binding (By
similarity).
-!- SIMILARITY: Belongs to the uvrB family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 660
MEEKFVLHSP FAPSGDQPEA IKALVDGIDE KKEHQVLLGV TGSGKTFTIA NVIAQLNRPS
LIISHNKTLA SQLYSELKAL FPDNRVEYFV SYFDFYKPEA YIPKSDLYIE KTSKNNKELE
AMRMSAINAL SIRKDTIVVA SVAAIYGESN PKHYRQNFFP IEVGMQIDRK SLLLKLSQIG
YERNRMELNK GQFDVKGDSI EICPGYVSDT NIRIDMFGNE IEAITLIDPL SKNVEGSRKN
MTLFPATTYT VHENTIQNTV DLIKQELSER IEYFKSHDKL LEAQRIKDRT LNDLDSLLEF
GYTSGIENYS RYLDGRAPGQ RPYTLFDYLP DDSVIFIDES HLMIPQLHGM HNGDRARKLS
LVEYGFRLPS ALDNRPLRFE EFAEFKFPKI YISATPGDYE LDLTHGEIVT QYIRPTGLLD
PIIEIHSRDN QIEDIYDHLK EQIAKKERTL ILTTTKKNAE ELSLFLQEKK IKSAYIHDRF
KIFERNEILK GLRMGKFDVV VGINLLKEGI DLPEVSLICV LNADSTGLMR DTRSLIQIVG
RAARNDHGKV IFYANEITSS MRECIEDNLF KRKIQSEYNE KHNIIPKTIV KPIAPPIQNG
ILSEDHSKYY GEKDLSQMKH NKKFIDQMVR KMTQLAKANK FEEAIEIRDY LIEIGIELDK