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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10529
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 25.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_MYCPU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL445565 | CAC13883.1 | - |
| PIR | F90600 | F90600. | |
| GenomeReviews | AL445566_GR | MYPU_7100.1 | |
| MypuList | MYPU_7100 | -. | |
| BioCyc | MPUL2107:MYPU_7100-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 1. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX MEDLINE=21267165; PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C.,
RA Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen
RT Mycoplasma pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
Feature:
CHAIN 1 944 UvrABC system protein A.
/FTId=PRO_0000093067.
DOMAIN 1 242 ABC transporter 1.
DOMAIN 359 597 ABC transporter 2.
DOMAIN 610 935 ABC transporter 3.
NP_BIND 34 41 ATP 1 (Potential).
ZN_FING 256 283 C4-type; degenerate.
NP_BIND 643 650 ATP 2 (Potential).
ZN_FING 744 770 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 3 ABC transporter domains.
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Sequence length: 944
MSKVDFLHIK GARENNLKNV ELTIPKNKLV IFTGLSGSGK SSLAFNTIYE EGRRRYVDSL
SSYARQFLGG TSKPDVDSIE GLSPAISIEQ KTTHNNPRST VGTVTEIYDY LRLLYARIGK
PFCPKHKIKI EGKTTKLIIE GIVDFPKNSK LIILSPVVEL EKGTHQKLIA KLKTEGFLRL
KINNEIVSLS DDKEINLDKN KRHSIDIVVD RIVLNEEKKL EISEAISIAL EYGKGIVKVE
NVETGEIKIF SSNHSCPKGD FEMPKIETRL FSFNSPYGMC QNCKGLGVQL RGDYNLLVPD
QNLSISEGAI KIFESTVNSS NQEWQEFEAL LNYYGIDKNI PMRKLSESDR QIIKYGSKEE
IDYIIKSQSN KFKRTKRIEG IIDKVERKYL ETSSEGIRTW IKRYMSEFIC NMCKGSRLNE
HALAVKINGL NIWEISSLSI NDVYEQSINL NLSDYEREIT TLLISELTSR LSFLVDVGLD
YLTLNRMAES LSGGEAQRIR LATQIGSNLT GVLYVLDEPS IGLHQKDNER LIKTLRKMVE
IGNTLIVVEH DEDTMRASDF IVDIGPKAGS HGGEIVALGS VEDIIKNPIS ITGKYLSGEW
QNATPKSRRS GSGNVIKITG ASQNNIKKLD FKIPLGKFIG VTGVSGSGKS TLINQVLVNA
IEKGIARDFS HDKNKNYEKI EGLLYIDKLI KISQSPIGRT PRSNPATYSS LFDDIREIFS
NVPEAKARGY QKGRFSFNVP GGRCEKCSGD GSIKIEMFFL PNVYITCDHC DGKRYNEETL
QIKYRSKSIS DVLDMTVSDA LAFFENRLIV KNKLQTLEDV GLGYIKLGQS STTLSGGEAQ
RVKLASHLLK KSTGKTLYVL DEPTTGLHSH DVSLLLKVLN RLVDKGDTVI VIEHNLDVIK
NCDYLIDLGP GGGVNGGKII ATGTPEQVAQ IEKSYTGEFL KRVL