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Description:
UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B).
Molecular weight: 76354
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRB_MYCPU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL445563 | CAC13269.1 | - |
| PIR | H90523 | H90523. | |
| HSSP | P56981 | 1D9X | |
| GenomeReviews | AL445566_GR | MYPU_0960.1 | |
| MypuList | MYPU_0960 | -. | |
| BioCyc | MPUL2107:MYPU_0960-MONOMER | -.1 | |
| HAMAP | MF_00204 | - | 1. |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR006935 | ResIII. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004807 | UvrB_ABC. | |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF04851 | ResIII | 1. |
| Pfam | PF02151 | UVR | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00631 | uvrb | 1. |
| PROSITE | PS50151 | UVR | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX MEDLINE=21267165; PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C.,
RA Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen
RT Mycoplasma pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
Feature:
CHAIN 1 657 UvrABC system protein B.
/FTId=PRO_0000138410.
DOMAIN 621 656 UVR.
NP_BIND 36 43 ATP (Potential).
MOTIF 89 112 Beta-hairpin.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. A damage recognition complex composed
of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon
binding of the uvrA(2)B(2) complex to a putative damaged site, the
DNA wraps around one uvrB monomer. DNA wrap is dependent on ATP
binding by uvrB and probably causes local melting of the DNA
helix, facilitating insertion of uvrB beta-hairpin between the DNA
strands. Then uvrB probes one DNA strand for the presence of a
lesion. If a lesion is found the uvrA subunits dissociate and the
uvrB-DNA preincision complex is formed. This complex is
subsequently bound by uvrC and the second uvrB is released. If no
lesion is found, the DNA wraps around the other uvrB subunit that
will check the other stand for damage (By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrA during the search for
lesions. Interacts with uvrC in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- DOMAIN: The beta-hairpin motif is involved in DNA binding (By
similarity).
-!- SIMILARITY: Belongs to the uvrB family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 657
MFKLHSNYSP SGDQPRAIQE LAEDIEKNKK HLVLQGVTGS GKTFTIANLI AKFNRTTLVL
SHNKTLASQL YSELKEFFPE NRVEYFVSYF DFYRPEAYLP STDTYIDKTS KTNNELDAMR
MSSLNALLTR KDTIVVSSVA AIYGAFNPQE YQKNFFSIEV GQELKRKDFF LDLVKRHYKR
NDVNLVPGSF SAKGDVVEIA PAWTSDFAIR VEFFGDEIEA IATIDPLNKT LKKRHKNYLI
FPANAYSTNK DIVSRVVLQV KEELIDRLDY FEKNNKLLEM QRLEQRVKSD MDSLEEFGIC
SGIENYARYI DGREQGEKPY TLLDYLPEEA LVFIDESHMM VPQLNAMFNG DRSRKQNLVD
YGFRLPSALD NRPLTFSEFE EYKFPKIYIS ATPSEYEIEK ADQKITKMII RPTGLLDPII
ETRSKTNQVE DIYDELQKQK AKNERTLILT TTKRFSEELT RYFQEKGEKV AYIHSDHKTF
ERNEILRKLR KGVYDLVIGI NLLREGIDLP EVSLVIILDA DKESFLRNTK SLIQIVGRAS
RNSSGKVIFY ADFVSKSMRE TIEDNFEKRQ IQIQYNKEHG IVPQTIIKDI PEPIEGHGFE
HSIEYFLSNE KKSKAQLKEK EKLILDLKKQ MLEASQKMNY ERAIHLRDLL IELGEKL