Description:
DNA polymerase I (EC 2.7.7.7) (POL I).
Molecular weight: 10197
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPO1_HELPY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000511 | AAD08510.1 | ALT_INIT |
| HSSP | P19821 | 1CMW | |
| GenomeReviews | AE000511_GR | HP1470.1 | |
| TIGR | HP1470 | -. | |
| InterPro | IPR002562 | 3_5_exonuclease. | |
| InterPro | IPR002421 | 5_3_exonuclease. | |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| Pfam | PF01367 | 5_3_exonuc | 1. |
| Pfam | PF02739 | 5_3_exonuc_N | 1. |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00474 | 35EXOc | 1. |
| SMART | SM00475 | 53EXOc | 1. |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00482 | POLAc | 1. |
| TIGRFAMs | TIGR00593 | pola | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=26695 / ATCC 700392;
RX MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
Feature:
CHAIN 1 891 DNA polymerase I.
/FTId=PRO_0000101241.
Comments:
-!- FUNCTION: In addition to polymerase activity, this DNA polymerase
exhibits 3' to 5' and 5' to 3' exonuclease activity (By
similarity).
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SUBUNIT: Single-chain monomer with multiple functions.
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
-!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
-!- SIMILARITY: Contains 1 5'-3' exonuclease domain.
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Sequence length: 891
MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM VKKFYKDRKN
MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI ALEWLQKMGF VCVEVNGFEA
DDVIASLATL SPYKTRIYSK DKDFNQLLSD KIALFDGKTE FLAKDCVEKY GILPSQFTDY
QGIVGDSSDN YKGVKGIGSK NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS
AFLSKELATL ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD
NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD KEKKVLALAF
LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH DLKPLLSFLK AKYQVPLENI
RIQDTQILAF LKNPEKVGFD EVLKEYLKEE LIPHEKIKDF KTKAEKLELL SVELNALKRL
CEYFEKGGLE ENLLSLAREI ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ
ILELIGVDFN LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN
KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK GLLIRKGFIA
SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH LETSKALFGE YLAKEKRSIA
KSINFGLVYG MGSKKLSETL NISLNEAKSY IEAYFKRFPS IKDYLNRMKE EILKTSKAFT
LLGRYRVFDF TGANDYVKGN YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ
VHDELIFEIE EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G