Description:
Transcription-repair coupling factor (EC 3.6.1.-) (TRCF) (ATP-dependent helicase mfd).
Molecular weight: 11309
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MFD_HELPY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000511 | AAD08581.1 | - |
| PIR | E64712 | E64712. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE000511_GR | HP1541.1 | |
| TIGR | HP1541 | -. | |
| InterPro | IPR003711 | CarD_TRCF. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004576 | Mfd. | |
| InterPro | IPR005118 | TRCF. | |
| Pfam | PF02559 | CarD_TRCF | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF03461 | TRCF | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00580 | mfd | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=26695 / ATCC 700392;
RX MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
Feature:
CHAIN 1 999 Transcription-repair coupling factor.
/FTId=PRO_0000102168.
NP_BIND 512 519 ATP (Potential).
MOTIF 609 612 DEEH box.
Comments:
-!- FUNCTION: Necessary for strand-specific repair. A lesion in the
template strand blocks the RNA polymerase complex (RNAP). The
RNAP-DNA-RNA complex is specifically recognized by TRCF which
releases RNAP and the truncated transcript; the TCRF may replace
RNAP at the lesion site and then recruit the uvrA/B/C repair
system (By similarity).
-!- SIMILARITY: In the N-terminal section; belongs to the uvrB family.
-!- SIMILARITY: In the C-terminal section; belongs to the helicase
family. RecG subfamily.
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Sequence length: 999
MIQSSLYRAL NKGFDYQILA CKDFKESELA KEVISYFKPN TKAILFPEFR AKKNDDLRSF
FEEFLQLLGG LREFYQALEN KQETIIIAPI SALLHPLPKK ELLESFKITL LEKYNLKDLK
DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY APNSKAYRLS FFDTECESIK EFDPITQMSL
KEDLLEIEIP PTLFSLDESS YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KAQDLLIVYK
SIISPRALEE IQELASLNEL DCERFKFLKV LENAQGYEDL EIHAHALEGF IALHSNHKIT
LLAPNKTILD NAISALDAGN MECVIAPFVL NFKTPDGIFI SLNSFERKKK RQKSKLALNE
LNPGEWVVHD DYGVGVFSQL VQHSVLGSKR DFLEIAYLGE DKLLLPVENL HLIARYVAQS
DSVPAKDRLG KGSFLKLKAK VRTKLLEIAS KIIELAAERN LILGKKMDVH LAELEVFKSH
AGFEYTSDQE KAIAEISKDL SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV
PTTLLAHQHF ETLRARFENF GVKVARLDRY ASEKNKLLKA VELGQVDALI GTHAILGAKF
KNLGLVVVDE EHKFGVKQKE ALKELSKSVH FLSMSATPIP RTLNMALSQI KGISSLKTPP
TDRKPSRTFL KEKNDELLKE IIYRELRRNG QIFYIHNHIA SILKVKTKLE DLIPKLKIAI
LHSQINANES EEIMLEFAKG NYQVLLCTSI VESGIHLPNA NTIIIDNAQN FGLADLHQLR
GRVGRGKKEG FCYFLIEDQK SLNEQALKRL LALEKNSYLG SGESVAYHDL EIRGGGNLLG
QDQSGHIKNI GYALYTRMLE DAIYELSGGK KRLEKSVEIQ LGVSAFLNPE LIASDSLRLD
LYRRLSLCEN TDEVGQIHEE IEDRFGKIDD LSAQFLQIIT LKILANQLGI IKLSNFNQNI
TITYSDEKKE SLKAPSKDDN DILETLLKHL RAQISLKRR