Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68680
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 1.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Helicobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_HELPY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000511 | AAD07868.1 | - |
| PIR | E64622 | E64622. | |
| HSSP | P13299 | 1MK0 | |
| GenomeReviews | AE000511_GR | HP0821.1 | |
| TIGR | HP0821 | -. | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=26695 / ATCC 700392;
RX MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
Feature:
CHAIN 1 594 UvrABC system protein C.
/FTId=PRO_0000138305.
DOMAIN 205 240 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 594
MADLLSSLKN LPNSSGVYQY FDKNRQLLYI GKAKNLKKRI KSYFSIRNNE ITPNHRASLR
IQMMVKQIAF LETILVENEQ DALILENSLI KQLKPKYNIL LRDDKTYPYI YMDFSTDFPI
PLITRKILKQ PGVKYFGPFT SGAKDILDSL YELLPLVQKK NCIKDKKACI FYQIERCKAP
CENKITKEEY LKIAKECLEM IENKDRLIKE LELKMERLSN NLRFEEALIY RDRIAKIQKI
APFTCMDLAK LYDLDIFAFY GASNKAVLVK MFMRGGKIIS SAFEKIHSLN GFDTDEAMKQ
AIINHYQSHL PLMPEQILLN ACSNETLKEL QEFISHQYSK KIALSIPKKG DKLALIEIAM
KNAQEIFSQE KTSNEDLILE EARSLFKLEC MPYRVEIFDT SHHSSSQCVG GMVVYENNAF
QKNSYRRYHL KGSDEYTQMS ELLTRRALDF AKEPPPNLWV IDGGRAQLNI ALEILKSSGS
FVEVIAISKE KRDSKAYRSK GGAKDIIHTP SDTFKLLPSD KRLQWVQKLR DESHRYAINF
HRSTKLKNMK QIALLKEKGI GEASVKKLLD YFGSFEAIEK ASEQEKNAVL KKRI