Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24570
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
07-MAR-2006, entry version 8.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Streptococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_STRA3:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL766849 | CAD46890.1 | - |
| HSSP | P13051 | 1AKZ | |
| GenomeReviews | AL732656_GR | gbs1231.1 | |
| SagaList | gbs1231 | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316 / Serotype III;
RX MEDLINE=22242508; PubMed=12354221;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L.,
RA Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P.,
RA Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing
RT invasive neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
Feature:
CHAIN 1 217 Uracil-DNA glycosylase.
/FTId=PRO_0000176145.
ACT_SITE 62 62 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 217
MKHSSWHDLI KRELPNHYYN KINTFMDAVY ESGIVYPPRD KVFNAIQITP LENVKVVIIG
QDPYHGPQQA QGLSFSVPDN LPAPPSLQNI LKELAEDIGS RSHHDLTSWA QQGVLLLNAC
LTVPEHQANG HAGLIWEPFT DAVIKVVNQK ETPVVFILWG GYARKKKSLI DNPIHHIIES
PHPSPLSAYR GFFGSRPFSR TNHFLEEEGI NEIDWLN