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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38678
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Bifidobacteriales Bifidobacteriaceae Bifidobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_BIFLO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014295 | AAN24546.1 | - |
| HSSP | Q56313 | 1IN5 | |
| GenomeReviews | AE014295_GR | BL0729.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR001984 | Peptidase_S16. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| PRINTS | PR00830 | ENDOLAPTASE. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705;
RX MEDLINE=22294977; PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B.,
RA Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M.,
RA Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation
RT to the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
Feature:
CHAIN 1 354 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165498.
NP_BIND 76 83 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 354
MSETTDYGAS NTGANEESLR MVSSQPIGNE PVSDEELRPH VLGGFIGQPR LKAQLQLFLD
AARKRDVPPD HILLAGPPGL GKTTLAMIVA NELEVPIRVT SGPAVQHAGD LASILSSLDV
GEVLFIDEIH RLPRAAEELL YIAMEDFRVD VMVGKGPGAS SIPLTLPRFT VIGATTREGM
LPSPLRARFG FTAHLDFYPH EELEKLIERS ANVLGVNLDT GSAHELALRS RGTPRIANRL
LRRVRDWAIV HDLIVVRPDD VKEALALYQI DSEGLDRLDI AVLNAIVRNF NGGPVGLNNL
AAMVGEESET VETVCEPYLV REGFMIRTPK GRVATEKAWQ HLGITPKDDV SKLF