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Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 23105
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Bifidobacteriales Bifidobacteriaceae Bifidobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_BIFLO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014295 | AAN25596.1 | - |
| HSSP | P12295 | 3EUG | |
| GenomeReviews | AE014295_GR | BL1812.1 | |
| BioCyc | BLON206672:BL1812-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705;
RX MEDLINE=22294977; PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B.,
RA Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M.,
RA Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation
RT to the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
Feature:
CHAIN 1 213 Uracil-DNA glycosylase.
/FTId=PRO_0000176069.
ACT_SITE 51 51 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 213
MADVEPTIHH MGDFLRAENA AGRPWLPASH NILRAFTIPF DSIKVLIVGQ DPYPTPGHPV
GLSFCVAPNV HPLPKSLVNI YKELVDDLGV PMPTNGDLTP WTERGVMLLN RCLTVGVGRP
NSHQGKGWEE VTEAAIRALN ARTDADGKPQ PLVAILWGRN AQSLEPLLTN AFIIKSPHPS
PLSASRGFFG SKPFSRANQA LVTMGADPVD WTL