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Description:
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]).
Molecular weight: 66790
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Archaea Euryarchaeota Methanococci Methanococcales Methanocaldococcaceae Methanocaldococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLI_METJA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L77117 | AAB98156.1 | - |
| PIR | D64321 | D64321. | |
| GenomeReviews | L77117_GR | MJ0171.1 | |
| TIGR | MJ0171 | -. | |
| BioCyc | MJAN243232:MJ0171-MONOMER | -.1 | |
| HAMAP | MF_00407 | - | 1. |
| InterPro | IPR000977 | DNA_ligase. | |
| InterPro | IPR012309 | DNA_ligase_A_C. | |
| InterPro | IPR012310 | DNA_ligase_A_M. | |
| InterPro | IPR012308 | DNA_ligase_A_N. | |
| PANTHER | PTHR10459 | DNA_ligase.1 | 1. |
| Pfam | PF04679 | DNA_ligase_A_C | 1. |
| Pfam | PF01068 | DNA_ligase_A_M | 1. |
| Pfam | PF04675 | DNA_ligase_A_N | 1. |
| TIGRFAMs | TIGR00574 | dnl1 | 1. |
| PROSITE | PS00697 | DNA_LIGASE_A1 | 1. |
| PROSITE | PS00333 | DNA_LIGASE_A2 | FALSE_NEG. |
| PROSITE | PS50160 | DNA_LIGASE_A3 | 1. |
Keywords:
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAL-1 / DSM 2661 / ATCC 43067;
RX MEDLINE=96337999; PubMed=8688087;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
Feature:
CHAIN 1 573 DNA ligase.
/FTId=PRO_0000059604.
ACT_SITE 250 250 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein seals, during DNA replication, DNA
recombination and DNA repair, nicks in double-stranded DNA (By
similarity).
-!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + diphosphate +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Sequence length: 573
MLWRDVCEIF NKIEKTTKRL EKRDYFIKLI DMVKEKGKPE DLKKICYMAI GRVYPEYDER
ELGIGEKLLI NAVTSIGIKK DELLEKIKET GDIGLAIEQL KSKIKQASLF FQPLTVDEVY
ETLKRVGEIE GEGSQKKKLR LISSLFLRAS PIECRYLARL ILEDMRIGMN VPTILDALSV
YFNVPKEKLE KIYAITNDIG LLAEKLLMGD LESEELKLKL FRPIKPMLAQ LTPSIEEALL
EMGRAQFETK YDGARVQIHK DGNKVKIYSR RLEDVTNALP EIVEAVKNIN VDKLIVEGEC
VAIDKQTGKP RPFQDILRRF RRKYDIGKMM KEINLRVYLF DILYKDGVSF IDEEFEKRRK
VLEEIVGYEN DWRTERKRIE KELKSDKIID ISYKLVTNDA KEAREFYNWS LSIGHEGVMI
KNLKAPYTPG SRVRTMYKFK PTLESLDVVI TKAKRGMGKR KDWYGSFEIC VRDEEGNLYP
IGHVGTGLTE ADLEFLKEEI DKIIIRDLGE EVEVEPKIVI EVAYEEIQKS DKYPCGYALR
FPRVVRFRFD KGVNEINTIE DVERIYEIQR GRK