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Description:
DNA repair and recombination protein radA.
Molecular weight: 39084
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Archaea Euryarchaeota Methanococci Methanococcales Methanocaldococcaceae Methanocaldococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RADA_METJA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U45312 | AAC44122.1 | - |
| EMBL | L77117 | AAB98875.1 | - |
| PIR | E64408 | E64408. | |
| HSSP | Q06609 | 1N0W | |
| SMR | Q49593 | 36-352.1 | |
| GenomeReviews | L77117_GR | MJ0869.1 | |
| TIGR | MJ0869 | -. | |
| BioCyc | MJAN243232:MJ0869-MONOMER | -.1 | |
| HAMAP | MF_00348 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR010214 | NusA_C_rpt. | |
| InterPro | IPR001553 | RecA_bac. | |
| InterPro | IPR011938 | Recomb_radA. | |
| Pfam | PF00633 | HHH | 2. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR01954 | nusA_Cterm_rpt | 1. |
| TIGRFAMs | TIGR02236 | recomb_radA | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=96251095; PubMed=8668545; DOI=10.1093/nar/24.11.2125;
RA Sandler S.J., Satin L.H., Samra H.S., Clark A.J.;
RT "recA-like genes from three archaean species with putative protein
RT products similar to Rad51 and Dmc1 proteins of the yeast Saccharomyces
RT cerevisiae.";
RL Nucleic Acids Res. 24:2125-2132(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAL-1 / DSM 2661 / ATCC 43067;
RX MEDLINE=96337999; PubMed=8688087;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
Feature:
CHAIN 1 352 DNA repair and recombination protein
radA.
/FTId=PRO_0000150095.
NP_BIND 136 143 ATP (Potential).
Comments:
-!- FUNCTION: Involved in DNA repair and in homologous recombination.
Binds and assemble on single-stranded DNA to form a nucleoprotein
filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes
DNA strand exchange between homologous DNA molecules.
-!- SIMILARITY: Belongs to the eukaryotic recA-like protein family.
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Sequence length: 352
MITFIYFFGN IIYYLPIYSY INNYKFMLMV IIMDDLTQLP GVGPTTAEKL KEAGYTDFMK
IATASIGELT EIDGISEKAA ARIIEAAREL CNLGFKSGTE VLSQRKNIWK LSTGSKNLDE
ILGGGLESQS VTEFAGMFGS GKTQIAHQAC VNLQCPERIV ADDAIKDEIL NEPKAVYIDT
EGTFRPERIV QMAEALGLDG NEVLNNIFVA RAYNSDMQML YAENVENLIR EGHNIKLVIV
DSLTSTFRTE YIGRGKLAER QQKLGRHMAT LNKLADIYNC VVIVTNQVAA RPDALFGPSE
QAIGGHIVGH AATFRIFLRK AKGDKRVAKL YDSPHLPDAE AMFRITEKGI HD