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Description:
Replication factor A (RP-A) (RF-A) (Replication factor-A protein 1)(Single-stranded DNA-binding protein) (mjaSSB).
Molecular weight: 73842
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
26-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Archaea Euryarchaeota Methanococci Methanococcales Methanocaldococcaceae Methanocaldococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RPA_METJA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L77117 | AAB99162.1 | - |
| PIR | F64444 | F64444. | |
| GenomeReviews | L77117_GR | MJ1159.1 | |
| TIGR | MJ1159 | -. | |
| BioCyc | MJAN243232:MJ1159-MONOMER | -.1 | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR004365 | OB_tRNA_NA_bd. | |
| Pfam | PF01336 | tRNA_anti | 4. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Metal-binding; Repeat; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAL-1 / DSM 2661 / ATCC 43067;
RX MEDLINE=96337999; PubMed=8688087;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP CHARACTERIZATION, SUBUNIT, AND DNA-BINDING.
RX MEDLINE=99061919; PubMed=9843941; DOI=10.1073/pnas.95.25.14634;
RA Kelly T.J., Simancek P., Brush G.S.;
RT "Identification and characterization of a single-stranded DNA-binding
RT protein from the archaeon Methanococcus jannaschii.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:14634-14639(1998).
Feature:
CHAIN 1 645 Replication factor A.
/FTId=PRO_0000097430.
DNA_BIND 78 158 OB 1.
DNA_BIND 186 266 OB 2.
DNA_BIND 291 378 OB 3.
DNA_BIND 423 497 OB 4.
ZN_FING 531 550 C4-type (Potential).
Comments:
-!- FUNCTION: Probably plays an essential for replication of the
chromosome, DNA recombination and repair (By similarity).
-!- SUBUNIT: Monomer. Binds to single-stranded DNA sequences.
-!- SIMILARITY: Contains 4 OB DNA-binding domains.
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Sequence length: 645
MIGDYERFKQ LKKKVAEALN ISEEELDRMI DKKIEENGGI ILKDAALMMI AKEHGVYGEE
KNDEEFLISD IEEGQIGVEI TGVITDISEI KTFKRRDGSL GKYKRITIAD KSGTIRMTLW
DDLAELDVKV GDVIKIERAR ARKWRNNLEL SSTSETKIKK LENYEGELPE IKDTYNIGEL
SPGMTATFEG EVISALPIKE FKRADGSIGK LKSFIVRDET GSIRVTLWDN LTDIDVGRGD
YVRVRGYIRE GYYGGLECTA NYVEILKKGE KIESEEVNIE DLTKYEDGEL VSVKGRVIAI
SNKKSVDLDG EIAKVQDIIL DNGTGRVRVS FWRGKTALLE NIKEGDLVRI TNCRVKTFYD
REGNKRTDLV ATLETEVIKD ENIEAPEYEL KYCKIEDIYN RDVDWNDINL IAQVVEDYGV
NEIEFEDKVR KVRNLLLEDG TGRIRLSLWD DLAEIEIKEG DIVEILHAYA KERGDYIDLV
IGKYGRIIIN PEGVEIKTNR KFIADIEDGE TVEVRGAVVK ILSDTLFLYL CPNCRKRVVE
IDGIYNCPIC GDVEPEEILR LNFVVDDGTG TLLCRAYDRR VEKMLKMNRE ELKNLTIEMV
EDEILGEEFV LYGNVRVEND ELIMVVRRVN DVDVEKEIRI LEEME