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Description:
DNA mismatch repair protein mutS.
Molecular weight: 10050
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Archaea Euryarchaeota Methanomicrobia Methanosarcinales Methanosarcinaceae Methanosarcina.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_METMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008384 | AAM31379.1 | - |
| HSSP | P23909 | 1OH6 | |
| GenomeReviews | AE008384_GR | MM1683.1 | |
| BioCyc | MMAZ192952:MM1683-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Goe1 / Go1 / ATCC BAA-199 / DSM 3647 / OCM 88;
RX MEDLINE=22120827; PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene
RT transfer between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Feature:
CHAIN 1 900 DNA mismatch repair protein mutS.
/FTId=PRO_0000115178.
NP_BIND 637 644 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 900
MTEMMTPAMR QYYEAKQAYP DTLIFFRMGD FYESFGEDAK TIAKELEITL TARGKDRSGE
RMPLAGIPYH AIDTYLPRLI NKGYKVAICE QLEDPKQAKG VVKRGVVRVV TPGTAIDSSM
FPDASNNYLM AVAGKEVGKT GKSGEKEMEF GLSFLDISTG EFLTTQFTDS GSFDKLLSEL
ARMKPAECIL PPTLYGNSVL VDRLREQTIV QEFAPEISGI EEAGEKLKIH FRVSTLEGMG
CEKLEFGVYS AWSALEYAKT TQMRDLAHIN TLRTYSNTEF MVLDSVTLRN LEIVKNVRDE
GDHNSLYRTL SFTKTPMGSR ILKKWLLKPL LSVEQINHRL DAVEELAGNP LLRYDIRDWL
SEVRDIERLV GRIVYGNANA RDLVALKKSL DAVPSIRDCL LEKAGAEMLK GIAEGLASFS
EIEELAKMIG NAIVEEPPVS VREGGMIKSG FSEELDELRD ISSNSKQWIA AFQQKEKDRT
GIKSLKIGYN KVFGYYIEVT NANSSQVPDD YIRKQTMANA ERFFTPELKE KESLILTAND
KAVALEYEIF TEITETLSAH SKELQETAER IGVLDVLADL AEVAENNNYT RPQLTEDCKI
LIRDGRHPVV ESTVSGGFVP NDTEMDCKEN QFLLVTGPNM AGKSTYMRQT ALIAIMAQAG
SFVPASYASI GVIDQVFTRI GAFDDLASGQ STFMVEMVEL ANILNNASPK SLVLLDEIGR
GTSTYDGYSI AKAVVEFLHN RGKVGIRALF ATHYHQLTSL EEKLKRVKNY HIAVKEEGHE
LVFLRKIVPG ATDRSYGIHV ARLAGVPEKV IERANEILRE LERESVLEES EDCENGKKRK
GKATTRYTQM LLFDPGSRSG NSEVKRGLSP VEAALKKMNV DEMTPIEAMN KLHELKKLLG