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Description:
DNA repair and recombination protein radA.
Molecular weight: 35126
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
29-AUG-2003, sequence version 2.
07-MAR-2006, entry version 21.
Phylogenetic order:
Archaea Euryarchaeota Methanomicrobia Methanosarcinales Methanosarcinaceae Methanosarcina.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RADA_METMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008384 | AAM30153.1 | ALT_INIT |
| HSSP | Q06609 | 1N0W | |
| GenomeReviews | AE008384_GR | MM0457.1 | |
| BioCyc | MMAZ192952:MM0457-MONOMER | -.1 | |
| HAMAP | MF_00348 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR010214 | NusA_C_rpt. | |
| InterPro | IPR001553 | RecA_bac. | |
| InterPro | IPR011938 | Recomb_radA. | |
| Pfam | PF00633 | HHH | 2. |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR01954 | nusA_Cterm_rpt | 1. |
| TIGRFAMs | TIGR02236 | recomb_radA | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Goe1 / Go1 / ATCC BAA-199 / DSM 3647 / OCM 88;
RX MEDLINE=22120827; PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene
RT transfer between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Feature:
CHAIN 1 325 DNA repair and recombination protein
radA.
/FTId=PRO_0000150096.
NP_BIND 107 114 ATP (Potential).
Comments:
-!- FUNCTION: Involved in DNA repair and in homologous recombination.
Binds and assemble on single-stranded DNA to form a nucleoprotein
filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes
DNA strand exchange between homologous DNA molecules (By
similarity).
-!- SIMILARITY: Belongs to the eukaryotic recA-like protein family.
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Sequence length: 325
MSEIALEELP GVGPATAEKL KEAGFNTIEA VAVASPSELA TTAEIGESTA AKIINAARQA
ADIGGFETGD LVLERRKLVG KLTTGCTEFD EMMGGGIETQ AITELYGEFG SGKTQVAHQL
AVNVQMDREH GGLGGSVIII DTENTFRPER ITQMVNGLSE KYGMELNPEE FLQNIHVARA
YNSNHQILLV DSAVDLANEL KEMGKPVRLL IVDSLMAHFR AEYVGRGTLA DRQQKLNKHM
HGLLRFGDLF NACVVVTNQV MAKPDAFFGD PTRPIGGHIV GHTATFRLYL RKSKGEKRII
RLVDSPSLPE GEAVVAVTTA GLTDQ