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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 60562
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 16.
Phylogenetic order:
Archaea Euryarchaeota Methanomicrobia Methanosarcinales Methanosarcinaceae Methanosarcina.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_METMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008384 | AAM32986.1 | - |
| GenomeReviews | AE008384_GR | MM3290.1 | |
| BioCyc | MMAZ192952:MM3290-MONOMER | -.1 | |
| HAMAP | MF_00203 | atypical | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Goe1 / Go1 / ATCC BAA-199 / DSM 3647 / OCM 88;
RX MEDLINE=22120827; PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene
RT transfer between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Feature:
CHAIN 1 523 UvrABC system protein C.
/FTId=PRO_0000138368.
DOMAIN 197 232 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 523
MGRGSKMIDL EALPHLPGCY LFKDEEGIVL YVGKAKDLKK RVSSYFQKRD HDPKTASLMQ
FARGLDFIVT NTEVEAFLLE NTLIKKHWPR YNIMLKDSKR YACIHLTGEK FPRIRIARKN
TGEGEFFGPF VSARERDYIF EVVRKTFQLR TCRKMPSRAC LRYHIGACSG PCISSVSVEE
YGEKVKKAIS VLKGNIRELI ESMETEMKEM AAKQMFEQAM ELRDEIAALE YLQEKQNMER
QKKYDEDILN YIVRDNNVYL MLFKVYKGTL EDKQDFVFAF GEDFLEEFLV QYYSENDPPE
ELIVPEPLDE SLVEFLAHVK GKKVKVAVPK QGDKKELLDL VLKNVEIGFF GDRKKLEALQ
SKLSLPKIPN VIECFDISHL SGTATVGSMV QFRGGRPDKH NYRRFKIESV EGIDDFASIA
EVVRRRYSRL LEDKHEMPDL IIIDGGKGQL SSAFQELRKL RVKVPIISIA KREEEIYVPG
LKSPLPIKKD EKASLFVQEI RDEAHRFAIN YNRLLRQKAL IQK