|
|
|
|
|
|
Description:
Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease)(Deoxyribonuclease V) (DNase V).
Molecular weight: 24872
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Archaea Euryarchaeota Archaeoglobi Archaeoglobales Archaeoglobaceae Archaeoglobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NFI_ARCFU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000782 | AAB91100.1 | - |
| PIR | A69266 | A69266. | |
| GenomeReviews | AE000782_GR | AF0129.1 | |
| TIGR | AF0129 | -. | |
| BioCyc | AFUL2234:AF0129-MONOMER | -.1 | |
| HAMAP | MF_00801 | - | 1. |
| InterPro | IPR007581 | Endonuc_V. | |
| Pfam | PF04493 | Endonuclease_5 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VC-16 / DSM 4304 / ATCC 49558;
RX MEDLINE=98049343; PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-
RT reducing archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
RN [2]
RP CHARACTERIZATION.
RX MEDLINE=20512198; PubMed=11056288; DOI=10.1016/S0921-8777(00)00054-9;
RA Liu J., He B., Qing H., Kow Y.W.;
RT "A deoxyinosine specific endonuclease from hyperthermophile,
RT Archaeoglobus fulgidus: a homolog of Escherichia coli endonuclease
RT V.";
RL Mutat. Res. 461:169-177(2000).
Feature:
CHAIN 1 221 Endonuclease V.
/FTId=PRO_0000159684.
Comments:
-!- FUNCTION: Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. Acts in DNA repair.
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR: Magnesium.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the endonuclease V family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 221
MLQMNLEELR RIQEEMSRSV VLEDLIPLEE LEYVVGVDQA FISDEVVSCA VKLTFPELEV
VDKAVRVEKV TFPYIPTFLM FREGEPAVNA VKGLVDDRAA IMVDGSGIAH PRRCGLATYI
ALKLRKPTVG ITKKRLFGEM VEVEDGLWRL LDGSETIGYA LKSCRRCKPI FISPGSYISP
DSALELTRKC LKGYKLPEPI RIADKLTKEV KRELTPTSKL K