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Description:
Probable N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNAglycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase(EC 4.2.99.18) (AP lyase)].
Molecular weight: 22639
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Archaea Euryarchaeota Archaeoglobi Archaeoglobales Archaeoglobaceae Archaeoglobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein OGG1_ARCFU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000782 | AAB90876.1 | - |
| PIR | C69296 | C69296. | |
| GenomeReviews | AE000782_GR | AF0371.1 | |
| TIGR | AF0371 | -. | |
| BioCyc | AFUL2234:AF0371-MONOMER | -.1 | |
| HAMAP | MF_00241 | - | 1. |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR012092 | Thrmst_ogg. | |
| Pfam | PF00730 | HhH-GPD | 1. |
| PIRSF | PIRSF005954 | Thrmst_ogg | 1. |
| SMART | SM00478 | ENDO3c | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Lyase; Multifunctional enzyme.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VC-16 / DSM 4304 / ATCC 49558;
RX MEDLINE=98049343; PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-
RT reducing archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
Feature:
CHAIN 1 198 Probable N-glycosylase/DNA lyase.
/FTId=PRO_0000159563.
ACT_SITE 122 122 By similarity.
Comments:
-!- FUNCTION: Responsible for removing an oxidatively damaged form of
guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks
DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).
-!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
apyrimidinic site in DNA is broken by a beta-elimination reaction,
leaving a 3'-terminal unsaturated sugar and a product with a
terminal 5'-phosphate.
-!- SIMILARITY: Belongs to the type-2 OGG1 family.
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Sequence length: 198
MIEKAISRRI KEFRQLGEKG EVEFDFRPFL DFSVKATIRT ELAFCISTAN SSATAGLKFQ
RLLGQGVGVK EALTLAGVRF HNRKAEYIRE AFKSFKLVEK ALEAESSKAR EILLKIKGLG
MKEASHFLRN VGREDVAIID RHILRWLERQ GYEVPGTMTA KKYLEVEKIL MEISEERGES
LAEMDLRIWA EMTGKVLK