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Description:
DNA repair and recombination protein radA.
Molecular weight: 37162
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Archaea Euryarchaeota Archaeoglobi Archaeoglobales Archaeoglobaceae Archaeoglobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RADA_ARCFU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000782 | AAB90248.1 | - |
| EMBL | AF090198 | AAD16064.1 | - |
| PIR | A69374 | A69374. | |
| HSSP | Q06609 | 1N0W | |
| GenomeReviews | AE000782_GR | AF0993.1 | |
| TIGR | AF0993 | -. | |
| BioCyc | AFUL2234:AF0993-MONOMER | -.1 | |
| HAMAP | MF_00348 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR010214 | NusA_C_rpt. | |
| InterPro | IPR001553 | RecA_bac. | |
| InterPro | IPR011938 | Recomb_radA. | |
| Pfam | PF00633 | HHH | 2. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR01954 | nusA_Cterm_rpt | 1. |
| TIGRFAMs | TIGR02236 | recomb_radA | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VC-16 / DSM 4304 / ATCC 49558;
RX MEDLINE=98049343; PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-
RT reducing archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 123-258.
RX MEDLINE=99121030; PubMed=9922255;
RA Sandler S.J., Hugenholtz P., Schleper C., DeLong E.F., Pace N.R.,
RA Clark A.J.;
RT "Diversity of radA genes from cultured and uncultured archaea:
RT comparative analysis of putative RadA proteins and their use as a
RT phylogenetic marker.";
RL J. Bacteriol. 181:907-915(1999).
Feature:
CHAIN 1 337 DNA repair and recombination protein
radA.
/FTId=PRO_0000150089.
NP_BIND 115 122 ATP (Potential).
Comments:
-!- FUNCTION: Involved in DNA repair and in homologous recombination.
Binds and assemble on single-stranded DNA to form a nucleoprotein
filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes
DNA strand exchange between homologous DNA molecules (By
similarity).
-!- SIMILARITY: Belongs to the eukaryotic recA-like protein family.
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Sequence length: 337
MSEESNEETK IIELEDIPGV GPETARKLRE AGYSTIEAVA VASPSELANV GGITEGNAVK
IIQAARKLAN IGGFESGDKV LERRRSVKKI TTGSKDLDEL LGGGVETQAI TEFFGEFGSG
KTQICHQLAV NVQLPEDEGG LEGSVIIIDT ENTFRPERII QMAEAKGLDG NEVLKNIYVA
QAYNSNHQML LVDNAKELAE KLKKEGRPVR LIIVDSLMSH FRAEYVGRGT LADRQQKLNR
HLHDLMKFGE LYNAAIVVTN QVMARPDVLF GDPTKPVGGH IVAHTATFRI YLKKGKDDLR
IARLIDSPHL PEGEAIFRVT ERGIEDAEEK DKKKRKK