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Description:
Thermostable DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase[ATP]).
Molecular weight: 67733
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLI_SULSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006656 | AAK40535.1 | - |
| PIR | H90159 | H90159. | |
| GenomeReviews | AE006641_GR | SSO0189.1 | |
| BioCyc | SSOL2287:SSO0189-MONOMER | -.1 | |
| HAMAP | MF_00407 | - | 1. |
| InterPro | IPR000977 | DNA_ligase. | |
| InterPro | IPR012309 | DNA_ligase_A_C. | |
| InterPro | IPR012310 | DNA_ligase_A_M. | |
| InterPro | IPR012308 | DNA_ligase_A_N. | |
| PANTHER | PTHR10459 | DNA_ligase.1 | 1. |
| Pfam | PF04679 | DNA_ligase_A_C | 1. |
| Pfam | PF01068 | DNA_ligase_A_M | 1. |
| Pfam | PF04675 | DNA_ligase_A_N | 1. |
| TIGRFAMs | TIGR00574 | dnl1 | 1. |
| PROSITE | PS00697 | DNA_LIGASE_A1 | 1. |
| PROSITE | PS00333 | DNA_LIGASE_A2 | 1. |
| PROSITE | PS50160 | DNA_LIGASE_A3 | 1. |
Keywords:
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / P2;
RX MEDLINE=21332296; PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
Feature:
CHAIN 1 601 Thermostable DNA ligase.
/FTId=PRO_0000059618.
ACT_SITE 260 260 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein seals, during DNA replication, DNA
recombination and DNA repair, nicks in double-stranded DNA (By
similarity).
-!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + diphosphate +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Sequence length: 601
MEFKVIAEYF DKLEKISSRL QLTALLADLL SKSDKTIIDK VVYIIQGKLW PDFLGYPELG
IGEKFLIKAI SIATNTDENS VENLYKTIGD LGEVARRLKS KQQSTGILGF LGTTSKESLT
VDEVYSTLSK VALTTGEGSR DLKIRLLAGL LKKADPLEAK FLVRFVEGRL RVGIGDATVL
DAMAIAFGGG QSASEIIERA YNLRADLGNI AKIIVEKGIE ALKTLKPQVG IPIRPMLAER
LSNPEEILKK MGGNAIVDYK YDGERAQIHK KEDKIFIFSR RLENITSQYP DVVDYVSKYI
EGKEFIIEGE IVAIDPESGE MRPFQELMHR KRKSDIYEAI KEYPVNVFLF DLMYYEDVDY
TTKPLEARRK LLESIVKPND YVKIAHHIQA NNVEDLKSFF YRAISEGGEG VMVKAIGKDA
IYQAGARGWL WIKLKRDYQS EMADTVDLVV VGGFYGKGKR GGKISSLLMA AYNPKTDSFE
SVCKVASGFS DEQLDELQKK LMEIKRDVKH PRVNSKMEPD IWVEPVYVAE IIGSEITISP
LHTCCQDVVE KDAGLSIRFP RFIRWRDDKS PEDATTTDEI LEMYNKQPKK KIESPAVDES
V