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Description:
Flap structure-specific endonuclease (EC 3.1.-.-).
Molecular weight: 39598
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
12-FEB-2003, sequence version 2.
07-MAR-2006, entry version 23.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein FEN_SULSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006656 | AAK40525.1 | ALT_INIT |
| HSSP | O93634 | 1B43 | |
| GenomeReviews | AE006641_GR | SSO0179.1 | |
| BioCyc | SSOL2287:SSO0179-MONOMER | -.1 | |
| HAMAP | MF_00614 | - | 1. |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
Keywords:
Complete proteome; Endonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / P2;
RX MEDLINE=21332296; PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
Feature:
CHAIN 1 349 Flap structure-specific endonuclease.
/FTId=PRO_0000154065.
METAL 154 154 Magnesium 1 (By similarity).
Comments:
-!- FUNCTION: Endonuclease that cleave the 5'overhanging flap
structure that is generated by displacement synthesis when DNA
polymerase encounters the 5'end of a downstream Okazaki fragment.
Has 5'endo-/exonuclease and 5'pseudo-Y-endonuclease activities.
Cleaves the junction between single and double-stranded regions of
flap DNA (By similarity).
-!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1
subfamily.
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Sequence length: 349
MDLADLVKDV KRELSFSELK GKRVSIDGYN ALYQFLAAIR QPDGTPLMDS QGRVTSHLSG
LFYRTINILE EGVIPIYVFD GKPPEQKSEE LERRRKAKEE AERKLERAKS EGKIEELRKY
SQAILRLSNI MVEESKKLLR AMGIPIVQAP SEGEAEAAYL NKLGLSWAAA SQDYDAILFG
AKRLVRNLTI TGKRKLPNKD VYVEIKPELI ETEILLKKLG ITREQLIDIG ILIGTDYNPD
GIRGIGPERA LKIIKKYGKI EKAMEYGEIS KKDINFNIDE IRGLFLNPQV VKPEEALDLN
EPNGEDIINI LVYEHNFSEE RVKNGIERLT KAIKEAKGAS RQTGLDRWF