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Description:
Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease)(Deoxyribonuclease V) (DNase V).
Molecular weight: 22051
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 18.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NFI_SULSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006844 | AAK42594.1 | - |
| PIR | C90417 | C90417. | |
| GenomeReviews | AE006641_GR | SSO2454.1 | |
| BioCyc | SSOL2287:SSO2454-MONOMER | -.1 | |
| LinkHub | Q97VZ6 | -.1 | |
| HAMAP | MF_00801 | - | 1. |
| InterPro | IPR007581 | Endonuc_V. | |
| Pfam | PF04493 | Endonuclease_5 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / P2;
RX MEDLINE=21332296; PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
Feature:
CHAIN 1 198 Endonuclease V.
/FTId=PRO_0000159695.
Comments:
-!- FUNCTION: Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. Acts in DNA repair (By similarity).
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR: Magnesium (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the endonuclease V family.
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Sequence length: 198
MVEKHLLEFL EKLQFLISKN VKISHYGIEN VKKICGVDIA YKGNLGFSVG VSMDINSGDY
NYKSYVGEVN FPYIPGFLFM REAPLMIKAI EGLDCHLLLV DGHGIAHPRK SGIAAVIGVL
LDFPTIGVAK SRLTGDLVNE SEITYVYLNG EKVGVKFGRY FYSPGNKVDL QDCIELGKRG
YPKVLKIADM LTKKIKKE