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Description:
Probable N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNAglycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase(EC 4.2.99.18) (AP lyase)].
Molecular weight: 24253
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein OGG1_SULSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006711 | AAK41186.1 | - |
| PIR | C90241 | C90241. | |
| GenomeReviews | AE006641_GR | SSO0904.1 | |
| BioCyc | SSOL2287:SSO0904-MONOMER | -.1 | |
| HAMAP | MF_00241 | - | 1. |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR012092 | Thrmst_ogg. | |
| Pfam | PF00730 | HhH-GPD | 1. |
| PIRSF | PIRSF005954 | Thrmst_ogg | 1. |
| SMART | SM00478 | ENDO3c | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Lyase; Multifunctional enzyme.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / P2;
RX MEDLINE=21332296; PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
Feature:
CHAIN 1 207 Probable N-glycosylase/DNA lyase.
/FTId=PRO_0000159566.
ACT_SITE 128 128 By similarity.
Comments:
-!- FUNCTION: Responsible for removing an oxidatively damaged form of
guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks
DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).
-!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
apyrimidinic site in DNA is broken by a beta-elimination reaction,
leaving a 3'-terminal unsaturated sugar and a product with a
terminal 5'-phosphate.
-!- SIMILARITY: Belongs to the type-2 OGG1 family.
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Sequence length: 207
MLRSLVQNPK VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS AYQALNCLGQ
KIYYANEEEI RNILKSCKYR FYNLKAKYII MAREKVYGRL KEEIKPLADE DQQLARERLL
NIKGIGMKEA SHFLRNVGYF DLAIIDRHII DFMRRIGAIG ETNVKQLSKS LYISFENILK
SIASNLNMSV GILDLFIWYK ETNTIVK