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Description:
Flap structure-specific endonuclease (EC 3.1.-.-).
Molecular weight: 38772
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 23.
Phylogenetic order:
Archaea Euryarchaeota Thermoplasmata Thermoplasmatales Thermoplasmataceae Thermoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein FEN_THEAC:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL445066 | CAC12164.1 | - |
| HSSP | O93634 | 1B43 | |
| GenomeReviews | AL139299_GR | Ta1035.1 | |
| BioCyc | TACI2303:TA1035-MONOMER | -.1 | |
| HAMAP | MF_00614 | - | 1. |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
Keywords:
Complete proteome; Endonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1728;
RX MEDLINE=20479972; PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
Feature:
CHAIN 1 336 Flap structure-specific endonuclease.
/FTId=PRO_0000154067.
METAL 153 153 Magnesium 1 (By similarity).
Comments:
-!- FUNCTION: Endonuclease that cleave the 5'overhanging flap
structure that is generated by displacement synthesis when DNA
polymerase encounters the 5'end of a downstream Okazaki fragment.
Has 5'endo-/exonuclease and 5'pseudo-Y-endonuclease activities.
Cleaves the junction between single and double-stranded regions of
flap DNA (By similarity).
-!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1
subfamily.
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Sequence length: 336
MGTDISDIVV SHETSLKDQG NQTFSIDTYN ILYQLLSNVR QYDGMPLMDS HGNVTSHLYG
IFYRTINLLE NRIRPVYVFD GKPSPLKNRT ISERQMMKEK AKAELEEAIE RGEEDLRQYY
SRINYITPQI VDDTKKLLDY MGIPYVDAPS EGEAQASYMT KKNVDGVISQ DYDCLLFGAR
KILRNFAIYG RRKVPRKNIY KTVYPEYIIL DEVLSANQIN QDQLIGIGIL VGTDFNEGIK
GIGAKKALAL IKKEGDIKSV LKHIGKNIEN LDEIIDFFKN PPVVDYDFKF RKPDTDAIEH
FLCDEHDFSR ERIRDHLESL RKNDQASTQF RLDSFD