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Description:
Probable N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNAglycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase(EC 4.2.99.18) (AP lyase)].
Molecular weight: 23690
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
10-OCT-2002, sequence version 2.
07-MAR-2006, entry version 22.
Phylogenetic order:
Archaea Euryarchaeota Thermoplasmata Thermoplasmatales Thermoplasmataceae Thermoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein OGG1_THEAC:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL445063 | CAC11163.1 | ALT_INIT |
| GenomeReviews | AL139299_GR | Ta0014.1 | |
| BioCyc | TACI2303:TA0014-MONOMER | -.1 | |
| HAMAP | MF_00241 | - | 1. |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR012092 | Thrmst_ogg. | |
| Pfam | PF00730 | HhH-GPD | 1. |
| PIRSF | PIRSF005954 | Thrmst_ogg | 1. |
| SMART | SM00478 | ENDO3c | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Lyase; Multifunctional enzyme.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1728;
RX MEDLINE=20479972; PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
Feature:
CHAIN 1 204 Probable N-glycosylase/DNA lyase.
/FTId=PRO_0000159568.
ACT_SITE 129 129 By similarity.
Comments:
-!- FUNCTION: Responsible for removing an oxidatively damaged form of
guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks
DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).
-!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
apyrimidinic site in DNA is broken by a beta-elimination reaction,
leaving a 3'-terminal unsaturated sugar and a product with a
terminal 5'-phosphate.
-!- SIMILARITY: Belongs to the type-2 OGG1 family.
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Sequence length: 204
MDSLISIPFL NDESVRSTIY RKVEEFRSIG KSSKEVLFKE LVFCILAANT SASMSLRMQE
SIGDGFLYLS RDDLRKALKE NKYRFYNVRS DFIVKSRNII DDLPALVASP DHEGSRDYLV
ENVYGIGYKE ASHFLRNVGI FDFAILDKHI MKWMAQYYPV KKNTSRKNYL YNEEIFRNIS
AGFGIEPGIL DLFIWYEETG TVIK