Description:
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]).
Molecular weight: 63337
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-MAR-2006, entry version 23.
Phylogenetic order:
Archaea Euryarchaeota Methanopyri Methanopyrales Methanopyraceae Methanopyrus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLI_METKA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE010389 | AAM02212.1 | - |
| GenomeReviews | AE009439_GR | MK0999.1 | |
| BioCyc | MKAN190192:MK0999-MONOMER | -.1 | |
| HAMAP | MF_00407 | - | 1. |
| InterPro | IPR000977 | DNA_ligase. | |
| InterPro | IPR012309 | DNA_ligase_A_C. | |
| InterPro | IPR012310 | DNA_ligase_A_M. | |
| InterPro | IPR012308 | DNA_ligase_A_N. | |
| PANTHER | PTHR10459 | DNA_ligase.1 | 1. |
| Pfam | PF04679 | DNA_ligase_A_C | 1. |
| Pfam | PF01068 | DNA_ligase_A_M | 1. |
| Pfam | PF04675 | DNA_ligase_A_N | 1. |
| TIGRFAMs | TIGR00574 | dnl1 | 1. |
| PROSITE | PS00697 | DNA_LIGASE_A1 | 1. |
| PROSITE | PS00333 | DNA_LIGASE_A2 | FALSE_NEG. |
| PROSITE | PS50160 | DNA_LIGASE_A3 | 1. |
Keywords:
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AV19 / DSM 6324 / JCM 9639;
RX MEDLINE=21927647; PubMed=11930014; DOI=10.1073/pnas.032671499;
RA Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L.,
RA Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O.,
RA Malykh A.G., Koonin E.V., Kozyavkin S.A.;
RT "The complete genome of hyperthermophile Methanopyrus kandleri AV19
RT and monophyly of archaeal methanogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
Feature:
CHAIN 1 559 DNA ligase.
/FTId=PRO_0000059605.
ACT_SITE 250 250 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein seals, during DNA replication, DNA
recombination and DNA repair, nicks in double-stranded DNA (By
similarity).
-!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + diphosphate +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Sequence length: 559
MYYSSLAEAF ERLERISSRK AKISLIAQFL RQCPEDVVDT VALFLANQVF PGWDPRDLGI
GSKLMRKVIA TATGSTDSEV TELFKRLGDL GLTAEELLKR RKTSTLLDSR PLMVGEVRET
FEKIAEVEGE GAVKRKMRLM MGLLARAKPK EARYLVRQAL SELRTGVRES TVEEAIAQAF
GVSRKLVERA HMLSNDLGLV AKVAMTKGEE GLREIDLRPM RPIKPMLAQA ARNVKEALAE
VGGKGAVEIK LDGARVQVHS DGEEVRVYTR RIEDVTHALP DIVEAVKDCV DADEFILEGE
AVAINPETGK PRPFQELLHR IKRKYDIEEV RKEIPVELHL FDCLYVDGES LVDTPFRERR
RRLEEIVRER EGEVMLVEQV ITDDPKEAAE MFHRALEMGH EGVMVKDLDA NYTPGVRGKK
MLKVKPVLET LDCVVIGGIW GKGKRKGLIG SYLLAVWDEN KENLLEVGKV GTGMDDETLE
RLTKMFEDLI VEESGREVRF KPEVVFEVEF EDIQKSPKYS SGFALRFPRL VRVRDDLGPE
DADTIEKVRR IYEEVLQKH