Description:
DNA mismatch repair protein mutS.
Molecular weight: 91066
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Thermotogae Thermotogales Thermotogaceae Thermotoga.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_THEMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U71155 | AAB16999.1 | - |
| EMBL | AE000512 | AAD36785.1 | - |
| PIR | C72219 | C72219. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE000512_GR | TM1719.1 | |
| TIGR | TM1719 | -. | |
| BioCyc | TMAR2336:TM1719-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wetmur J.G., Rosenfeld A., Wong D.M.;
RT "Hyperthermophilic MutS proteins: isolation, characterization and
RT enhancement of PCR specificity.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSB8 / DSM 3109 / ATCC 43589;
RX MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
Feature:
CHAIN 1 793 DNA mismatch repair protein mutS.
/FTId=PRO_0000115158.
NP_BIND 589 596 ATP (Potential).
CONFLICT 233 233 A -> G (in Ref. 1).
CONFLICT 262 262 L -> W (in Ref. 1).
CONFLICT 287 287 L -> G (in Ref. 1).
CONFLICT 506 506 K -> T (in Ref. 1).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 793
MKVTPLMEQY LRIKEQYKDS ILLFRLGDFY EAFFEDAKIV SKVLNIVLTR RQDAPMAGIP
YHALNTYLKK LVEAGYKVAI CDQMEEPSKS KKLIRREVTR VVTPGSIVED EFLSETNNYM
AVVSEEKGRY CTVFCDVSTG EVLVHESSDE QETLDLLKNY SISQIICPEH LKSSLKERFP
GVYTETISEW YFSDLEEVEK AYNLKDIHHF ELSPLALKAL AALIKYVKYT MIAEDLNLKP
PLLISQRDYM ILDSATVENL SLIPGDRGKN LFDVLNNTET PMGARLLKKW ILHPLVDRKQ
IEERLKAVER LVNDRVSLEE MRNLLSNVRD VERIVSRVEY NRSVPRDLVA LRETLEIIPK
LNEVLSTFGV FKKLAFPEGL VDLLRKAIED DPVGSPGEGK VIKRGFSSEL DEYRDLLEHA
EERLKEFEEK ERERTGIQKL RVGYNQVFGY YIEVTKANLD KIPDDYERKQ TLVNSERFIT
PELKEFETKI MAAKERIEEL EKELFKSVCE EVKKHKEVLL EISEDLAKID ALSTLAYDAI
MYNYTKPVFS EDRLEIKGGR HPVVERFTQN FVENDIYMDN EKRFVVITGP NMSGKSTFIR
QVGLISLMAQ IGSFVPAQKA ILPVFDRIFT RMGARDDLAG GRSTFLVEMN EMALILLKST
NKSLVLLDEV GRGTSTQDGV SIAWAISEEL IKRGCKVLFA THFTELTELE KHFPQVQNKT
ILVKEEGKNV IFTHKVVDGV ADRSYGIEVA KIAGIPDRVI NRAYEILERN FKNNTKKNGK
SNRFSQQIPL FPV