Description:
Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease)(Deoxyribonuclease V) (DNase V).
Molecular weight: 25598
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Thermotogae Thermotogales Thermotogaceae Thermotoga.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NFI_THEMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000512 | AAD36927.1 | - |
| PIR | B72202 | B72202. | |
| GenomeReviews | AE000512_GR | TM1865.1 | |
| TIGR | TM1865 | -. | |
| BioCyc | TMAR2336:TM1865-MONOMER | -.1 | |
| LinkHub | Q9X2H9 | -.1 | |
| HAMAP | MF_00801 | - | 1. |
| InterPro | IPR007581 | Endonuc_V. | |
| Pfam | PF04493 | Endonuclease_5 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSB8 / DSM 3109 / ATCC 43589;
RX MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
Feature:
CHAIN 1 225 Endonuclease V.
/FTId=PRO_0000159674.
Comments:
-!- FUNCTION: Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. Acts in DNA repair (By similarity).
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR: Magnesium (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the endonuclease V family.
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Sequence length: 225
MDYRQLHRWD LPPEEAIKVQ NELRKKIKLT PYEGEPEYVA GVDLSFPGKE EGLAVIVVLE
YPSFKILEVV SERGEITFPY IPGLLAFREG PLFLKAWEKL RTKPDVVVFD GQGLAHPRKL
GIASHMGLFI EIPTIGVAKS RLYGTFKMPE DKRCSWSYLY DGEEIIGCVI RTKEGSAPIF
VSPGHLMDVE SSKRLIKAFT LPGRRIPEPT RLAHIYTQRL KKGLF