Description:
Putative Holliday junction resolvase (EC 3.1.-.-).
Molecular weight: 24916
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Thermotogae Thermotogales Thermotogaceae Thermotoga.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVX_THEMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000512 | AAD36612.1 | - |
| PIR | E72243 | E72243. | |
| GenomeReviews | AE000512_GR | TM1545.1 | |
| TIGR | TM1545 | -. | |
| BioCyc | TMAR2336:TM1545-MONOMER | -.1 | |
| HAMAP | MF_00651 | atypical | 1. |
| InterPro | IPR005227 | HJR_YqgF. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| InterPro | IPR006641 | YqgFc. | |
| Pfam | PF03652 | UPF0081 | 1. |
| SMART | SM00732 | YqgFc | 1. |
Keywords:
Complete proteome; DNA damage; DNA recombination; DNA repair; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSB8 / DSM 3109 / ATCC 43589;
RX MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
Feature:
CHAIN 1 218 Putative Holliday junction resolvase.
/FTId=PRO_0000172162.
Comments:
-!- FUNCTION: Could be a nuclease that resolves Holliday junction
intermediates in genetic recombination.
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the yqgF HJR family.
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Sequence length: 218
MDIQLFQGYG GKVIVAVDYG ERKCGVAFGE ILPQKSLVIP TKNLKEFIRK LKPDKIIFGL
PLSMSGKYTQ QTFKTVAVAF KFSKEYETYL CDERLTTKIG ERISKRDDAV SAALIFQSFF
ENSSVCEKVT DPRKKVDLAL EKVDGEVLLY EFPDPSLNIE AREVDVVTKN PVLAYFYSKN
GYFVGRELWE KKYDLIISGK NCEELKKYLK ENGRLVCL