Description:
Single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein).
Molecular weight: 16298
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Thermotogae Thermotogales Thermotogaceae Thermotoga.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein SSB_THEMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000512 | AAD35689.1 | - |
| PIR | H72354 | H72354. | |
| PDB | 1Z9F | X-ray | A=1-141. |
| GenomeReviews | AE000512_GR | TM0604.1 | |
| TIGR | TM0604 | -. | |
| BioCyc | TMAR2336:TM0604-MONOMER | -.1 | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR011344 | Single_strand_bd. | |
| InterPro | IPR000424 | SSB_primosomal_n. | |
| InterPro | IPR010913 | ssDNA_bd. | |
| Pfam | PF00436 | SSB | 1. |
| TIGRFAMs | TIGR00621 | ssb | 1. |
| PROSITE | PS50935 | SSB | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSB8 / DSM 3109 / ATCC 43589;
RX MEDLINE=99287316; PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
Feature:
CHAIN 1 141 Single-stranded DNA-binding protein.
/FTId=PRO_0000096128.
DOMAIN 4 108 SSB.
STRAND 2 2
STRAND 4 15
STRAND 18 21
STRAND 27 36
STRAND 50 58
HELIX 59 68
TURN 71 72
STRAND 74 84
STRAND 96 106
Comments:
-!- FUNCTION: This protein is essential for replication of the
chromosome. It is also involved in DNA recombination and repair
(By similarity).
-!- SIMILARITY: Contains 1 SSB domain.
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Sequence length: 141
MSFFNKIILI GRLVRDPEER YTLSGTPVTT FTIAVDRVPR KNAPDDAQTT DFFRIVTFGR
LAEFARTYLT KGRLVLVEGE MRMRRWETPT GEKRVSPEVV ANVVRFMDRK PAETVSETEE
ELEIPEEDFS SDTFSEDEPP F