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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10689
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Xanthomonadales Xanthomonadaceae Xylella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_XYLFA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE004051 | AAF85225.1 | - |
| PIR | C82560 | C82560. | |
| HSSP | P58301 | 1F2U | |
| GenomeReviews | AE003849_GR | Xf2426.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9a5c;
RX MEDLINE=20365717; PubMed=10910347; DOI=10.1038/35018003;
RA Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M.,
RA Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S.,
RA Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S.,
RA Bueno M.R.P., Camargo A.A., Camargo L.E.A., Carraro D.M., Carrer H.,
RA Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M.,
RA Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H.,
RA Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A.,
RA Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R.,
RA Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A.,
RA Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P.,
RA Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C.,
RA Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A.,
RA Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L.,
RA Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y.,
RA Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B.,
RA Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S.,
RA Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A.,
RA de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A.,
RA Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B.,
RA Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M.,
RA de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E.,
RA da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr.,
RA da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A.,
RA de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H.,
RA Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L.,
RA Zago M.A., Zatz M., Meidanis J., Setubal J.C.;
RT "The genome sequence of the plant pathogen Xylella fastidiosa.";
RL Nature 406:151-159(2000).
Feature:
CHAIN 1 965 UvrABC system protein A.
/FTId=PRO_0000093118.
DOMAIN 344 588 ABC transporter 1.
DOMAIN 605 937 ABC transporter 2.
NP_BIND 32 39 ATP (Potential).
ZN_FING 254 281 C4-type.
NP_BIND 641 648 ATP (Potential).
ZN_FING 740 766 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 965
MTALIRIRGA RTHNLKNLDL DLPRNTLIVI TGLSGSGKSS LAFDTIYAEG QRRYVESLSA
YARQFLSVME KPDLDQIEGL SPAISIEQKS TSHNPRSTVG TITEIYDYLR LLYARVGQPR
CPDHHYPLEA QTVSQMVDHV LTLDPEQRYM LLAPVVRERK GEHTQVFEQL RAQGFVRVRV
DGELYEIDVV PTLTLRQKHT IEAVIDRFRP REDIKQRLAE SFETALKLGN GMASVQTLDT
TTTTPHLFSS KYSCPVCDYS LPELEPRLFS FNAPMGACPA CNGLGVTEFF DPAKVVIHPD
LSLSAGAVRG WDRRNAYYFQ LIASLAKHYT FDIDASWESL PEEIRHTILF GSGDEQINFI
YLTEAGGRTK RKHRFEGIVP NLERRYRETE SAAVREELAK YVSTRTCPEC GGTRLNRAAR
NVFVADRTLP ELTVLPINDA LEFFKTLRLP GWRGEIAIKI VKEIGERLGF LVDVGLDYLT
LERKADTLSG GEAQRIRLAS QIGAGLVGVM YVLDEPSIGL HQRDNERLLG TLTRLRDLGN
TVIVVEHDED AIRQADHILD IGPGAGVHGG EICAQGSLEQ IMAAPRSLTG QYLSGRRRIE
IPKQRHPPNA TKMLHLRGAC GNNLKGVNLD IPEGLFTCIT GVSGSGKSTL INDTLFTLAA
NEINGASHPI APYASVDGLE LFDKVVDIDQ SPIGRTPRSN PATYTGMFTP LRELFAQVPE
ARARGYSPGR FSFNVRGGRC EACEGDGLIK VEMHFLPDVY VPCDVCHGKR YNRETLEIRY
KGYNINDVLE MTVEDALKLF EAVPAIARKL ETLVDVGLSY LKLGQSATTL SGGEAQRVKL
SKELSRRDTG RTLYILDEPT TGLHFYDIEA LLAVLHKLRD AGNTVIVIEH NLDVIKTADW
VIDLGPEGGG RGGEILVAGT PEAVAAHPHS HTGHFLAKLL PPKDVSNCGH RDPGEEVDIA
QTVHR