Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10631
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_MYCPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000026 | BAC44701.1 | - |
| GenomeReviews | BA000026_GR | MYPE9100.1 | |
| BioCyc | MPEN28227:MYPE9100-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HF-2;
RX MEDLINE=22354719; PubMed=12466555; DOI=10.1093/nar/gkf667;
RA Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT "The complete genomic sequence of Mycoplasma penetrans, an
RT intracellular bacterial pathogen in humans.";
RL Nucleic Acids Res. 30:5293-5300(2002).
Feature:
CHAIN 1 952 UvrABC system protein A.
/FTId=PRO_0000093065.
DOMAIN 349 602 ABC transporter 1.
DOMAIN 605 944 ABC transporter 2.
NP_BIND 38 45 ATP (Potential).
ZN_FING 258 285 C4-type.
NP_BIND 648 655 ATP (Potential).
ZN_FING 747 773 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 952
MNNKVNTRDF IVVKGARENN LKNVDIDIPK NKFVVMTGLS GSGKSSLAFD TIYAEGQRRY
LESLSSYARQ FLGGNEKPDV DSIEGLSPAI SIDQKTTSHN PRSTVGTVTE IYDYLRLLFS
RIGKPYCPNG HGLISTLSIK QMIDTVYENK EESKIQILSP IISQEKGTFK NKIEELKRQG
YLRLRIDGNI YSLDDEIELE KTKKHNIDIL IDRIILNNDT VTRSRIYDAI EKSVKEANGK
VIVLVDDKEL FFSQNHACNE CGFSIPELEP RFFSFNSPVG ACKSCNGIGF NFLPDTAKIV
PDPSLSIKEG AIAYFRSVMM TPTMDLKREM SVWKEHDINL DVPFKELSKK EKNIIFYGDE
DIGELKIDVN EQSIYSSSSF LYNNGLVNLI MRRFSETQSE RAREYYEKFM SNLSCPSCNG
QKLSIEALSV KINNKNIIDL TEKNINDLTN FFIELELNET DRNIAHLALK EIVDRLSFLE
NVGLNYLTLS RSASTLSGGE SQRIRLATQI GSSLTGVLYV LDEPSIGLHQ KDNEKLIETL
KKMRDLGNTL IVVEHDEDTI RASDYLIDIG PKAGDFGGEV VAAGTVSEVS ENKKSITAQY
LSGKLKIEVP SKRRHGNGKT IELVGASGNN LKNVTVSFPL NKLIAVTGVS GSGKSTLINE
TLIKGIEKKL TNPFIVPAPF KDIKGLKNVD KIIKVSQDPI GRTPRSNPAT YVSVFDDIRD
LFANTKEAKA RGFQKGRFSF NVSGGRCENC SGDGLIKIEM HFLPDVFVKC ESCNGKKYNQ
ETLQVLYKGK SIYDVLEMSV VEARDFFYEI PEIKRKLDLM VEVGIDYLKL GTSSTHLSGG
EAQRIKLAKY LQKRATGKTI YVLDEPTTGL HIHDIAKLIT VLNRIVDNGD TVIVVEHNLD
LIKCADYVID LGPDGGINGG QLVAYGTPEE IIEKKAVSYT GLFLEKNMYK DK