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Description:
DNA mismatch repair protein mutL.
Molecular weight: 69748
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 24.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_PSEAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE004907 | AAG08331.1 | - |
| PIR | F83028 | F83028. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE004091_GR | PA4946.1 | |
| BioCyc | PAER287:PA4946-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RX MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
Feature:
CHAIN 1 633 DNA mismatch repair protein mutL.
/FTId=PRO_0000177958.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 633
MSEAPRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD AGSRRIDVEV EQGGIKLLRV
RDDGRGIPAD DLPLALARHA TSKIRELEDL ERVMSLGFRG EALASISSVA RLTMTSRTAD
AGEAWQVETE GRDMQPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLRAEKT EFDHLQEVIK
RLALARFDVA FHLRHNGKTI FALHEARDEL ARARRVGAVC GQAFLEQALP IEVERNGLHL
WGWVGLPTFS RSQPDLQYFY VNGRMVRDKL VAHAVRQAYR DVLYNGRHPT FVLFFEVDPA
VVDVNVHPTK HEVRFRDSRM VHDFLYGTLH RALGEVRPDD QLAPPGATSL TEPRPTGAAA
GEFGPQGEMR LAESVLESPA ARVGWSGGSS ASGGSSGYSA YTRPEAPPSL AEAGGAYKAY
FAPLPAGEAP AALPESAQDI PPLGYALAQL KGIYILAENA HGLVLVDMHA AHERITYERL
KVAMASEGLR GQPLLVPESI AVSEREADCA EEHSSWFQRL GFELQRLGPE SLAIRQIPAL
LKQAEATQLV RDVIADLLEY GTSDRIQAHL NELLGTMACH GAVRANRRLT LPEMNALLRD
MEITERSGQC NHGRPTWTQL GLDELDKLFL RGR