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Description:
DNA mismatch repair protein mutS.
Molecular weight: 94978
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_PSEAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF126491 | AAF36440.1 | - |
| EMBL | AF220055 | AAF42850.1 | - |
| EMBL | AE004782 | AAG07008.1 | - |
| PIR | B83193 | B83193. | |
| HSSP | P23909 | 1OH6 | |
| GenomeReviews | AE004091_GR | PA3620.1 | |
| BioCyc | PAER287:PA3620-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hex1T;
RA Pezza R.J., Smania A.M., Argarana C.E.;
RT "Cloning and nucleotide sequence of Pseudomonas aeruginosa MutS
RT gene.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RA Blazquez J.;
RT "Cloning and sequencing of mutS gene from Pseudomonas aeruginosa.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RX MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
Feature:
CHAIN 1 855 DNA mismatch repair protein mutS.
/FTId=PRO_0000115121.
NP_BIND 613 620 ATP (Potential).
CONFLICT 649 650 VD -> AV (in Ref. 1).
CONFLICT 660 660 D -> DX (in Ref. 2).
CONFLICT 781 781 A -> T (in Ref. 1).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 855
MTDLSQHTPM MQQYFKLKHQ HPDQLMFYRM GDFYELFYED AKKAAKLLDI TLTARGQSGG
KAIPMAGIPF HSAEGYLAKL VKLGESVAIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
LLDERRDNLL AAILGDERLF GLAVLDITSG RFSVQEIKGW ETLLAELERL NPAELLIPDD
WPQGLPAEKR RGVRRRAPWD FDRDSAHKSL CQQFGTQDLK GFGCQNLTLA IGAAGCLLAY
AKETQRTALP HLRSLRHDRL DDTVILDGAS RRNLELDINL SGGRENTLQS VVDRCQTAMA
SRLMSRWLNR PLRDRAVLEA RQESIACLLE RYRFENLQPQ LKEIGDLERI LARIGLRNAR
PRDLARLRDA LAALPDLQNA MTELEAPHLQ ALATTIGTYP ELAELLAKAI IDNPPAVIRD
GGVIKTGYDA ELDELQALSE NAGQFLMDLE AREKARTGLP NLKVGYNRIH GYFIELPRVQ
AEQAPADYIR RQTLKGAERF ITPELKAFED KALSAQSRAL AREKALYEEL LERLIGHLAP
LQDSASALAE LDVLANLAER ALNLDLNRPR FVEHTCLHIE QGRHPVVEQV LETPFVANDL
ALDADTRMLV ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AARCELSLVD RIFTRIGSSD
DLAGGRSTFM VEMSETANIL HNATDKSLVL MDEVGRGTST FDGLSLAWAA AEDLARTRAF
TLFATHYFEL TVLPESQPAV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
APVIQRAREH LKRLETTSLP HEMPSQQSGK PASPMQSDLF ASLPHPVIDE LSRINPDDIS
PRQALDLLYA WKMRV