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Description:
Protein recA (Recombinase A).
Molecular weight: 36879
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
07-MAR-2006, entry version 54.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECA_PSEAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X05691 | CAA29173.1 | - |
| EMBL | X52261 | CAA36504.1 | - |
| EMBL | D13090 | NOT_ANNOTATED_CDS | |
| EMBL | AE004782 | AAG07005.1 | - |
| PIR | S06265 | RQPSAA. | |
| HSSP | P03017 | 2REB | |
| SMR | P08280 | 2-327.1 | |
| GenomeReviews | AE004091_GR | PA3617.1 | |
| BioCyc | PAER287:PA3617-MONOMER | -.1 | |
| HAMAP | MF_00268 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| Pfam | PF00154 | RecA | 1. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02012 | tigrfam_recA | 1. |
| PROSITE | PS00321 | RECA_1 | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO;
RX MEDLINE=88038334; PubMed=2823059; DOI=10.1007/BF00328132;
RA Sano Y., Kageyama M.;
RT "The sequence and function of the recA gene and its protein in
RT Pseudomonas aeruginosa PAO.";
RL Mol. Gen. Genet. 208:412-419(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAM 7;
RA Zaitsev E.N., Krjukov V.M., Kuzmin N.P., Alekseev A.A., Lanzov V.A.;
RL Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=91182156; PubMed=2127886;
RA Kryukov V.M., Zaitsev E.N., Kouzmin N.P., Bayev A.A.;
RT "Structure of the Pseudomonas aeruginosa recA gene.";
RL Bioorg. Khim. 16:1177-1182(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO;
RX MEDLINE=93224470; PubMed=8468303;
RA Sano Y.;
RT "Role of the recA-related gene adjacent to the recA gene in
RT Pseudomonas aeruginosa.";
RL J. Bacteriol. 175:2451-2454(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RX MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
Feature:
CHAIN 1 346 Protein recA.
/FTId=PRO_0000122801.
NP_BIND 65 72 ATP (By similarity).
CONFLICT 333 333 V -> L (in Ref. 3).
Comments:
-!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of
single-stranded DNA, the ATP-dependent uptake of single-stranded
DNA by duplex DNA, and the ATP-dependent hybridization of
homologous single-stranded DNAs. It interacts with lexA causing
its activation and leading to its autocatalytic cleavage.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recA family.
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Sequence length: 346
MDENKKRALA AALGQIERQF GKGAVMRMGD HERQAIPAIS TGSLGLDIAL GIGGLPKGRI
VEIYGPESSG KTTLTLSVIA EAQKQGATCA FVDAEHALDP DYAGKLGVNV DDLLVSQPDT
GEQALEITDM LVRSNAVDVI IVDSVAALVP KAEIEGEMGD AHVGLQARLM SQALRKITGN
IKNANCLVIF INQIRMKIGV MFGNPETTTG GNALKFYASV RLDIRRTGAV KEGDEVVGSE
TRVKVVKNKV SPPFRQAEFQ ILYGKGIYRT GEIIDLGVQL GLVEKSGAWY SYQGSKIGQG
KANAAKYLED NPEIGSVLEK TIRDQLLAKS GPVKADAEEV ADAEAD