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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10448
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_PSEAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE004840 | AAG07622.1 | - |
| PIR | E83117 | E83117. | |
| GenomeReviews | AE004091_GR | PA4234.1 | |
| BioCyc | PAER287:PA4234-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RX MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
Feature:
CHAIN 1 945 UvrABC system protein A.
/FTId=PRO_0000093078.
DOMAIN 310 593 ABC transporter 1.
DOMAIN 607 937 ABC transporter 2.
NP_BIND 31 38 ATP (Potential).
ZN_FING 254 281 C4-type.
NP_BIND 640 647 ATP (Potential).
ZN_FING 740 766 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 945
MDKILIRGAR THNLKNVDLT LPRDKLIVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY
ARQFLSMMEK PDVDTIEGLS PAISIEQKST SHNPRSTVGT ITEIYDYLRL LYARVGTPRC
PDHDIPLEAQ TVSQMVDQVL ALPEGSKLML LAPVIRERKG EHLAVFDEMR AQGFVRARVD
GKLYELDEVP KLDKQKKHSI DVVVDRFKVR ADLQQRLAES FETALSLADG IALVAPMDED
EDVEEIIFSA RFACPVCGHS ISELEPKLFS FNNPAGACPT CDGLGVKQFF DARRVVNGEL
TLAEGAIRGW DRRNVYYFQM LGSLAQHYGF SLEEPFDELG AEHQKVVLYG SGRENVDFRY
LNDRGDIVKR SHPFEGILPN LERRYRETES ATVREELAKF LSTQPCPDCH GTRLRREARH
VWVGDRTLPA ITAMPVGEAC EYAAGLSLTG RRGEIAAKIL KEIRDRLQFL VNVGLDYLTL
DRSADTLSGG EAQRIRLASQ IGAGLVGVMY ILDEPSIGLH QRDNERLLGT LTHLRNLGNT
VIVVEHDEDA IRLADYVVDI GPGAGVHGGQ VVAEGTPDQV MNHPDSLTGK YLSGRKKIAV
PAKRTPRDKK KLLKLKGARG NNLQNVNLEI PVGLFTCITG VSGSGKSTLI NNTLFPITAT
ALNGATTLEV APYDSFDGLQ HLDKVVDIDQ SPIGRTPRSN PATYTGLFTP IRELFSGVPE
ARSRGYGPGR FSFNVKGGRC EACQGDGVIK VEMHFLPDIY VPCDVCKGKR YNRETLEIRY
KGKSIHEVLE MTIEEAREFF DAVPALARKL QTLMDVGLSY IKLGQSATTL SGGEAQRVKL
SRELSKRDTG KTLYILDEPT TGLHFADIQQ LLDVLHRLRD HGNTVVVIEH NLDVIKTADW
LVDLGPEGGS KGGQIIANGT PEQVAEMPQS HTGHFLKPLL ERDRA