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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 67352
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_PSEAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE004687 | AAG05973.1 | - |
| PIR | C83322 | C83322. | |
| GenomeReviews | AE004091_GR | PA2585.1 | |
| BioCyc | PAER287:PA2585-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / PAO1;
RX MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT opportunistic pathogen.";
RL Nature 406:959-964(2000).
Feature:
CHAIN 1 608 UvrABC system protein C.
/FTId=PRO_0000138326.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 608
MSAVFDASAF LATCSNRPGV YRMFDAEAKL LYVGKAKSLK KRLASYFRKS GLAPKTAALV
ARIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK SYPFVFLSSE DEYPRLSLHR
GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV
GLVSPEEYAE DVRHSVMFLE GRSNALADEL NVGMEQAAMR LDFEKAAELR DQVAILRRVQ
DQQSMEGGNG DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL
GQYYLSHQER DLPAELIVNV THEDFPVLVS AIAEARGREL EISYRVRGTR ARWQQLAVTN
AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI SHSSGEATVA SCVVFGPEGP
LKSDYRRYNI EGVTAGDDYA AMHQALTRRF SRLKDGEGKM PDILLVDGGK GQLAMAQEVL
QELAVAGLIL LGVAKGVTRK PGLETLYLND ASHEFTLPAD SPALHLIQQI RDEAHRFAIT
GHRARRGKAR RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ
IYAVLHSE