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Description:
DNA mismatch repair protein mutL.
Molecular weight: 66783
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
07-MAR-2006, entry version 9.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Brucellaceae Brucella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_BRUME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009735 | AAL54268.1 | - |
| PIR | AI3637 | AI3637. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE008918_GR | BMEII1026.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / Biotype 1;
RX MEDLINE=20020109; PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen
RT Brucella melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Feature:
CHAIN 1 623 DNA mismatch repair protein mutL.
/FTId=PRO_0000177929.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 623
MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG KTLLRVTDNG
SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI GSVSKLTLKS RPQDADSGFE
VCVTGGHLDG PRPTALNRGT IVEVRDLFYA TPARLKFMKT DRAEATAITD VVKRIGIAFP
HIRFSLAGTD RTPFEMPATG TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI
PSFNRGNALH QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV
HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG FGAQQSAPRP
ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL RENGQAVLGD VAVPAADARA
SVAEAPVELM QKPLGAARAQ IHENYIVAQT EDSLVIVDQH AAHERLVYEA LKNALHARPI
AGQMLLIPEI VDLPEEDAQR LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL
IRDLADEIAE HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT
CNHGRPTYIE LKLTDIERLF GRR