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Description:
DNA mismatch repair protein mutS.
Molecular weight: 98808
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Brucellaceae Brucella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BRUME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009613 | AAL52982.1 | ALT_INIT |
| PIR | AC3477 | AC3477. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE008917_GR | BMEI1801.1 | |
| BioCyc | BMEL29459:BMEI1801-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / Biotype 1;
RX MEDLINE=20020109; PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen
RT Brucella melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Feature:
CHAIN 1 910 DNA mismatch repair protein mutS.
/FTId=PRO_0000115077.
NP_BIND 658 665 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 910
MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA
ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG
SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALAWID ISTGTFRVAE
TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH
YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS
LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT
LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA
AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ
ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE
LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ
GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN
MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE
TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS
EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL
EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI
YKLKELAGKA