Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68077
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Brucellaceae Brucella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_BRUSU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE014291 | AAN29628.1 | - |
| GenomeReviews | AE014291_GR | BR0699.1 | |
| TIGR | BR0699 | -. | |
| BioCyc | BSUI204722:BR0699-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330 / Biovar 1;
RX MEDLINE=22247741; PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A.,
RA Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O.,
RA Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M.,
RA Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between
RT animal and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
Feature:
CHAIN 1 611 UvrABC system protein C.
/FTId=PRO_0000138291.
DOMAIN 194 229 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 611
MKRLPNNPGV YRMFNSDGDV LYVGKARNLK KRVSNYARGI GHSNRITRMI RETVTMEFVV
TRTETEALLL EANLIKRSRP RFNVLMRDDK SFPYILLTGG HRAPGIFKHR GARSRKGDYF
GPFASAGAVG RTINALQRAF LLRTCTDSVF ETRTRPCLLY QIKRCSAPCT YEISDEDYAG
LVAEAKAFLS GKSQSVKDHL AAAMQAASAD LDFEHAAVYR DRLAALSHVQ SHQGINPQTV
EEADVFAIHQ EGGMTCIQVF FFRTGQNWGN RAYFPKADSS LGPAEVLGAF LSQFYDDKPC
PKLVLLSETV EEQSLITEAL STRAGHKVQV SVPQRGEKKE LVQHALTNAR EALGRRLAET
SSQARLLQGL AETFGLPRAP RRIEVYDNSH IMGTNAVGGM IVAGPEGFVK NQYRKFNIRS
TDITPGDDFG MMREVIERRF SRLVKEHGTP AGEVENPDAF PAWPDVILID GGQGQVGAVR
QILGEMGISD LVTAIGIAKG VDREAGRERF FMEGKQPFTL PPRDPVLYFI QRLRDEAHRF
AIGTHRARRK KEMVRNPLDE IAGIGPTRKR ALLHHFGTAK AVSRAAVEDL MQIDGISEAM
ARAIHDHFRD K