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Description:
DNA mismatch repair protein mutL.
Molecular weight: 68732
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Burkholderiaceae Ralstonia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_RALSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL646070 | CAD16270.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AL646052_GR | RSc2563.1 | |
| BioCyc | RSOL305:RSC2563-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX MEDLINE=21681879; PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA Arlat M., Billault A., Brottier P., Camus J.C., Cattolico L.,
RA Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
Feature:
CHAIN 1 636 DNA mismatch repair protein mutL.
/FTId=PRO_0000177961.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 636
MTAATPARRP IRPLPDQLIS QIAAGEVVER PASVVKELLE NALDAGATQL QIKLEEGGVR
RIAITDNGGG IPVDELPVAL MRHATSKIGS LEELESVATL GFRGEALASI ASVAELTLTS
RTAQDAHATQ IIAQTGRVQP ASGGVGTTVD VQHLYFNTPA RRKFLKTEQT ELGHCLEVIR
RTALARPDVA ISVHHNGKPL EHWNAAQADM RTAAVLGTEF ARARLPFEEA AGELRLFGFA
GLPTASRGRA DHQFFYVNGR FVRDRLLTHA VRSAYEDVLH GDRFPAYVLC LELPPEAVDV
NVHPSKIEVR FRDSRAVHQF VYHAVQRALS RHAGEQGDSL RTDIADAPEQ PGATATPADN
TTRWVNQMAA RQTSLGIAQP RAEYLAMMRG GSAPQPSSRP AWMADVPSAA TLFDGAASAP
ADAAPAQASE PAAAPQADDS DDAHPLGFAV AQLHGIYVLA QNARGMVLVD MHAAHERILY
EQLKTALEAR RIEVQPLLIP VTFAASPVEI GTAEEFGDTL DLLGFDISAV SPTTLAVRAV
PTLLQKADAQ ALARDVLRDL QAYGGSRVLA ERQNELLATL ACHSAVRANR RLNLDEMNAL
LRQMEATERA DQCNHGRPTW IQLTVADLDR LFLRGQ