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Description:
DNA mismatch repair protein mutS.
Molecular weight: 96264
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Burkholderiaceae Ralstonia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_RALSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL646063 | CAD14853.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AL646052_GR | RSc1151.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX MEDLINE=21681879; PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA Arlat M., Billault A., Brottier P., Camus J.C., Cattolico L.,
RA Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
Feature:
CHAIN 1 882 DNA mismatch repair protein mutS.
/FTId=PRO_0000115124.
NP_BIND 629 636 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 882
MAEHSAPALE IDPKYGPFDK HTPMMQQYLK LKSAHPHTLV FYRMGDFYEL FFEDAEKAAR
LLDITLTSRG TTNGQPIRMA GVPFHAVEQY LAKLVKLGES VAICEQIGDP ATTKGPVERK
VVRVVTPGTL TDAALLSDKV NNHLLAIAQI PGKRGAAPLV GLAWLNLVGG ELRLMECSAE
QLDRELERIR PAEVLADDAT LNAVAFDVAR TRLPDWHFDV EAGARRLREQ LGVASLVAFG
CETLTAALAA AGALLNYAAA TQGQSLRHVI GLTVEHESEF IGLDTATRRN LELTETLRGQ
ESPTLFSLLD TCATSMGSRL LRHWLHHPLR DRAVPQARQQ AIEVLLAGDW QSLRGTLRTL
SDVERITGRL ALLSARPRDL SSLRDTLARL PEVRDQLPQS DDAQLLGDLH AALAIPEDAH
ALLQRAVMAE PAAMVRDGGV IARGYDADLD ELRDISENCG QFLVDLEARE RERTGIANLR
VEYNRVHGFY IEVTNGQAAK VPDDYRRRQT LKNAERYITP ELKAFEDKAL SAQDRALSRE
KYLYEDLLQK LLPHLPVLKR IAAALAQADV LATLAERAHA LSWSRPALTD APGIELIRAR
HPVVEQQVEQ FVANDCVLQE TRKLLLITGP NMGGKSTFMR QTALVVLLAY VGAFVPADAA
TIGPIDRIFT RIGAADDLAG GRSTFMVEMT EAAAILHRAT PNSLVLMDEI GRGTSTFDGL
ALAWAIARHL LSHNRSHTLF ATHYFELTQL PQEFAQAANV HLSAVEHGDG IVFLHAVQEG
PASQSYGLQV AQLAGVPQPV IRAARKRLAW LEQHSADTGA TPQLDLFALP SDPSDDDAAE
AAAPAAPSAL AEALDGIDPD SMTPRDALDA LYRLKALSDA SA