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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 39059
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 31.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Burkholderiaceae Ralstonia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_RALSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL646059 | CAD14028.1 | - |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | AL646052_GR | RSc0500.1 | |
| BioCyc | RSOL305:RSC0500-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR001984 | Peptidase_S16. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| PRINTS | PR00830 | ENDOLAPTASE. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX MEDLINE=21681879; PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA Arlat M., Billault A., Brottier P., Camus J.C., Cattolico L.,
RA Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
Feature:
CHAIN 1 357 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165581.
NP_BIND 73 80 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 357
MIETDKLAAK AVSAERLISA SPASPNEEAF ERALRPKLLD EYVGQEKVRG QLDIFMTAAK
KRREALDHVL LFGPPGLGKT TLAHIIAREM GVNLRQTSGP VLERPGDLAA LLTNLEANDV
LFIDEIHRLS PVVEEILYPA LEDYQIDIMI GEGPAARSVK LDLQPFTLVG ATTRAGMLTN
PLRDRFGIVA RLEFYTPTEL ARIVTRSAGL LDARIAEDGA LEIAKRSRGT PRIANRLLRR
VRDYAEVKAD GVITRAVADA ALAMLDVDAV GFDLMDRKLL EAILHKFNGG PVGIDNLAAA
IGEERDTIED VLEPYLIQQG YLQRTPRGRV ATASAYQHFG LGAPKTGPAR DLWDNNA