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Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 28666
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Burkholderiaceae Ralstonia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_RALSO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL646072 | CAD16594.1 | - |
| HSSP | P12295 | 3EUG | |
| GenomeReviews | AL646052_GR | RSc2887.1 | |
| BioCyc | RSOL305:RSC2887-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX MEDLINE=21681879; PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA Arlat M., Billault A., Brottier P., Camus J.C., Cattolico L.,
RA Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
Feature:
CHAIN 1 266 Uracil-DNA glycosylase.
/FTId=PRO_0000176131.
ACT_SITE 97 97 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 266
MTRRADPAQA TLFDDDEPAG APTATGGFVP LADQFDALPA DWKALLGPCL ARTDWPALCA
FVDGERAAGK PIFPTEVFHA LHLTPVDAVR VIILGQDPYH GTGTVDGREV PQAHGLAFSV
PAGVRVPPSL RNIYKEIEAE YGRKLSAGSG NLEGWAQQGV LLLNTVLTVE QGQAASHARR
GWERITDCLL EHLARVGHAR VFMLWGSHAQ AKRALLPEGH LVLEAPHPSP LSAHRGFLGC
GHFRAANDWL AAQGQSTIDW LRPQAD