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Description:
DNA mismatch repair protein mutL.
Molecular weight: 70972
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_PSESM:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016853 | AAO58372.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE016853_GR | PSPTO4944.1 | |
| TIGR | PSPTO4944 | -. | |
| BioCyc | PSYR223283:PSPTO4944-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DC3000;
RX MEDLINE=22834015; PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F.,
RA Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H.,
RA Nelson W.C., Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q.,
RA Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J.,
RA Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M.,
RA Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K.,
RA Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X.,
RA Bender C.L., White O., Fraser C.M., Collmer A.;
RT "The complete genome sequence of the Arabidopsis and tomato pathogen
RT Pseudomonas syringae pv. tomato DC3000.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
Feature:
CHAIN 1 645 DNA mismatch repair protein mutL.
/FTId=PRO_0000177960.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 645
MTDLLLDGSE ADNAQTVLNA ARIELLSPRL ANQIAAGEVV ERPASVIKEL LENSLDSGAR
RIDIDVEQAG IKLLKVRDDG GGISSDDLPL ALARHATSKI RDLEDLERVM SLGFRGEALA
SISSVARLTL TSRTRDADQA WQVETEGRDM DARVQPAAHP VGTSVEVRDL FFNTPARRKF
LKAEKTEFDH LHEVIKRMAL ARFDVAFHLR HNGKTVLSLH EAHDDTARAR RVSAICGPGF
LEQALPIEIE RNGLHLWGWV GLPTFSRSQA DLQYFFVNGR AVRDKLVAHA VRQAYRDVLF
NGRHPTFVLF FEVDPAAVDV NVHPTKHEVR FRDGRMVHDF LYGTLHRALG DVRPENQLGG
SVPAAAEPRP TGPDAGEFGP QGEMRLANNV LEQPQGEPFA RPAGGGSGSG YQYSPRPTTG
VPVAEAQSAY REFFAPLPGT TPSALPESPS DIPPLGYALA QLKGIYILAE NAHGLVLVDM
HAAHERIMYE RLKIAMANEG LSGQPLLVPE SIAVSQREAD CAEEHITTFQ RLGFELQRLG
PETLAIRQIP ALLKQAEANR LVSDVLADLM EYGTSDRVQA HMNELLGTMA CHGAIRANRR
LAIPEMNGLL RDMENTERSG QCNHGRPTWT QMGLSDLDKL FLRGQ