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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 67113
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 1.
07-MAR-2006, entry version 24.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_PSESM:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016853 | AAO56513.1 | - |
| GenomeReviews | AE016853_GR | PSPTO3023.1 | |
| TIGR | PSPTO3023 | -. | |
| BioCyc | PSYR223283:PSPTO3023-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DC3000;
RX MEDLINE=22834015; PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F.,
RA Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H.,
RA Nelson W.C., Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q.,
RA Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J.,
RA Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M.,
RA Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K.,
RA Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X.,
RA Bender C.L., White O., Fraser C.M., Collmer A.;
RT "The complete genome sequence of the Arabidopsis and tomato pathogen
RT Pseudomonas syringae pv. tomato DC3000.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
Feature:
CHAIN 1 607 UvrABC system protein C.
/FTId=PRO_0000138329.
DOMAIN 203 238 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 607
MTQTFDPSAF LATCSGRPGV YRMFDADATL LYVGKAKNLK KRLASYFRKT GHAPKTGALV
ARIAQIETTI TNNETEALLL EQTLIKEWRP PYNILLRDDK SYPYVFLSDG TYPRLSIHRG
AKKAKGRYFG PYPSAGAIRE SLSLLQKTFQ VRQCEDSFFK NRNRPCLQYQ IKRCKGPCVG
LVEPEVYAED VRHSVMFLEG RSNALSDELN ASMEKAAMAL DFERAAELRD QVALLRRVQD
QQSMDGGTGD VDVVAAFVNP GGACVHLISV RGGRVLGSKN FFPQVGIEEE VGEVMSAFLA
QYFLGGVDRE LPSEVIVNVV NEDFPALIDA IEESRGREMT ISHRVRGTRA RWQQLAVTNA
EQALAARLAN RQHVASRFEA LAVVLNLDEP PMRLECYDIS HSSGEATVAS CVVFGPEGPI
KSDYRRFNIE GVTAGDDYAA MHQALTRRYS RIKAGEGKLP DVLLVDGGKG QMSMARDVLN
ELQVPDLILL GVAKGTTRKA GFETLYLNDA AHEFTLPGDS PALHLIQQIR DEAHRFAITG
HRARRGKTRR TSTLEGIAGV GPTRRRDLLK HFGGLQELSR ASIDEIAKAP GISKKLAESI
YANLHSE