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Protein data for 3MG_ARATH:

Description:
DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNAglycosidase).

Molecular weight: 28133

View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )


Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 39.

Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.

To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html

Links to references in other databases for protein 3MG_ARATH:

DatabasePointerAdd. info#1Add. info#2
EMBLX76169CAA53763.1-
EMBLAP002040BAB03116.1-
EMBLAC069473AAG51039.1-
HSSPP293721F4R
GenomeReviewsBA000014_GRAT3G12040.1
TAIRAt3g12040-.1
InterProIPR003180PurDNA_glycsylse.
PANTHERPTHR10429PurDNA_glycsylse.11.
PfamPF02245Pur_DNA_glyco1.
ProDomPD009649PurDNA_glycsylse1.
TIGRFAMsTIGR005673mg1.

General information about the databases mentioned above

Keywords:
DNA damage; DNA repair; Hydrolase; Nuclear protein.

References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia; TISSUE=Aerial parts;
RX MEDLINE=94181568; PubMed=8134381;
RA Santerre A., Britt A.B.;
RT "Cloning of a 3-methyladenine-DNA glycosylase from Arabidopsis
RT thaliana.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:2240-2244(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20363099; PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II.
RT Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC
RT and BAC clones.";
RL DNA Res. 7:217-221(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=21016720; PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M.,
RA Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B.,
RA Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P.,
RA De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P.,
RA Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V.,
RA Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S.,
RA Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G.,
RA Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B.,
RA Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G.,
RA Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J.,
RA Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D.,
RA Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D.,
RA Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W.,
RA Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J.,
RA Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P.,
RA Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S.,
RA Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V.,
RA Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C.,
RA Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E.,
RA Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y.,
RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:820-822(2000).

Feature:
CHAIN 1 254 DNA-3-methyladenine glycosylase.
/FTId=PRO_0000100068.

Comments:
-!- FUNCTION: Hydrolysis of the deoxyribose N-glycosidic bond to
excise 3-methyladenine, and 7-methylguanine from the damaged DNA
polymer formed by alkylation lesions (By similarity).
-!- CATALYTIC ACTIVITY: Hydrolysis of alkylated DNA, releasing 3-
methyladenine, 3-methylguanine, 7-methylguanine and 7-
methyladenine.
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
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Sequence length: 254

     MKTPARRSKR VNQEESETNV TTRVVLRTRK TNCSKTRAAR VRPDYPLTRT TSESEMKLMP
     PEFFQIDALD LAPRLLGKFM RRDNVVLRIT EVEAYRPNDS ACHGRFGVTP RTAPVFGPGG
     HAYVYLCYGL HMMLNIVADK EGVGAAVLIR SCSPVSGMET IQERRGLKTD KPVLLNGPGK
     VGQALGLSTE WSHHPLYSPG GLELLDGGED VEKVMVGPRV GIDYALPEHV NALWRFAVAD
     TPWISAPKNT LKPL

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