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Description:
DNA mismatch repair protein MSH2 (AtMsh2).
Molecular weight: 10550
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 36.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH2_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF026549 | AAB81282.1 | - |
| EMBL | AF109243 | AAD04176.1 | - |
| EMBL | AF002706 | AAB82649.1 | - |
| EMBL | AF003005 | AAB82650.1 | - |
| EMBL | AB026658 | BAB01119.1 | - |
| EMBL | AP001303 | BAB01119.1 | JOINED |
| EMBL | U87911 | AAD00647.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | BA000014_GR | AT3G18524.1 | |
| TAIR | At3g18524 | -.1 | |
| InterPro | IPR011184 | MSH2. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| PIRSF | PIRSF005813 | MSH2 | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RX MEDLINE=98002338; PubMed=9342879; DOI=10.1104/pp.115.2.833;
RA Culligan K.M., Hays J.B.;
RT "DNA mismatch repair in plants. An Arabidopsis thaliana gene that
RT predicts a protein belonging to the MSH2 subfamily of eukaryotic MutS
RT homologs.";
RL Plant Physiol. 115:833-839(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX MEDLINE=99444907; PubMed=10517319; DOI=10.1007/s004380051080;
RA Ade J., Belzile F., Philippe H., Doutriaux M.P.;
RT "Four mismatch repair paralogues coexist in Arabidopsis thaliana:
RT AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2.";
RL Mol. Gen. Genet. 262:239-249(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20277480; PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 665-781.
RA Cerovic G., Radman M.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 937 DNA mismatch repair protein MSH2.
/FTId=PRO_0000115187.
NP_BIND 666 673 ATP (Potential).
VARIANT 404 404 T -> A (in strain: cv. Landsberg erecta).
VARIANT 468 468 S -> N (in strain: cv. Landsberg erecta).
VARIANT 624 624 S -> L (in strain: cv. Landsberg erecta).
VARIANT 737 737 S -> T (in strain: cv. Landsberg erecta).
VARIANT 902 902 I -> M (in strain: cv. Landsberg erecta).
CONFLICT 781 781 F -> Y (in Ref. 4).
Comments:
-!- FUNCTION: Involved in postreplication mismatch repair. Binds
specifically to DNA containing mismatched nucleotides thus
providing a target for the excision repair processes
characteristic of postreplication mismatch repair (By similarity).
-!- SUBUNIT: Heterodimer of MSH2 and MSH6 (GTBP) (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 937
MEGNFEEQNK LPELKLDAKQ AQGFLSFYKT LPNDTRAVRF FDRKDYYTAH GENSVFIAKT
YYHTTTALRQ LGSGSNALSS VSISRNMFET IARDLLLERN DHTVELYEGS GSNWRLVKTG
SPGNIGSFED VLFANNEMQD TPVVVSIFPS FHDGRCVIGM AYVDLTRRVL GLAEFLDDSR
FTNLESSLIA LGAKECIFPA ESGKSNECKS LYDSLERCAV MITERKKHEF KGRDLDSDLK
RLVKGNIEPV RDLVSGFDLA TPALGALLSF SELLSNEDNY GNFTIRRYDI GGFMRLDSAA
MRALNVMESK TDANKNFSLF GLMNRTCTAG MGKRLLHMWL KQPLVDLNEI KTRLDIVQCF
VEEAGLRQDL RQHLKRISDV ERLLRSLERR RGGLQHIIKL YQSTIRLPFI KTAMQQYTGE
FASLISERYL KKLEALSDQD HLGKFIDLVE CSVDLDQLEN GEYMISSSYD TKLASLKDQK
ELLEQQIHEL HKKTAIELDL QVDKALKLDK AAQFGHVFRI TKKEEPKIRK KLTTQFIVLE
TRKDGVKFTN TKLKKLGDQY QSVVDDYRSC QKELVDRVVE TVTSFSEVFE DLAGLLSEMD
VLLSFADLAA SCPTPYCRPE ITSSDAGDIV LEGSRHPCVE AQDWVNFIPN DCRLMRGKSW
FQIVTGPNMG GKSTFIRQVG VIVLMAQVGS FVPCDKASIS IRDCIFARVG AGDCQLRGVS
TFMQEMLETA SILKGASDKS LIIIDELGRG TSTYDGFGLA WAICEHLVQV KRAPTLFATH
FHELTALAQA NSEVSGNTVG VANFHVSAHI DTESRKLTML YKVEPGACDQ SFGIHVAEFA
NFPESVVALA REKAAELEDF SPSSMIINNE ESGKRKSRED DPDEVSRGAE RAHKFLKEFA
AIPLDKMELK DSLQRVREMK DELEKDAADC HWLRQFL